S. Thameem Dheen

TL;DR: A comprehensive review of recent findings of mechanisms and signaling pathways by which microglial cells are activated in CNS inflammatory diseases and various forms of potential therapeutic options to inhibit the microglia activation which amplifies the inflammation-related neuronal injury in neurodegenerative diseases are summarized.

TL;DR: In this paper, the role of some chemokines and their receptors in the trafficking of rat mesenchymal stem cells (rMSCs) in a rat model of left hypoglossal nerve injury was examined.

TL;DR: This review gives a detailed account of the microglia-mediated neuroinflammation in various neurodegenerative diseases and shows great promise as a novel treatment strategy to reduce neuronal damage and to foster a permissive environment for further regeneration effort.

TL;DR: Activated microglia TLR4 presents as a potential therapeutic target for neonatal hypoxia brain injuries after its roles in neuroinflammation in neonatal rats following hypoxic injury are investigated.

TL;DR: Evidence that activation of either the NF-κB and MAPK signaling pathways was partly responsible for inducing the expression and activation of NLRP1 and NLRP3 inflammasome proteins is provided and that these effects can be attenuated using pharmacological inhibitors of these two pathways in neurons and brain tissue under in vitro and in vivo ischemic conditions, respectively is provided.