S
Sabarish Ramachandran
Researcher at Texas Tech University Health Sciences Center
Publications - 46
Citations - 1780
Sabarish Ramachandran is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Cancer & Mammary tumor. The author has an hindex of 17, co-authored 41 publications receiving 1364 citations. Previous affiliations of Sabarish Ramachandran include Georgia Regents University & Keimyung University.
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Journal ArticleDOI
Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line.
Jung Kyu Park,Chi Heum Cho,Sabarish Ramachandran,So Jin Shin,Sanghoon Kwon,Sun Young Kwon,Soon Do Cha +6 more
TL;DR: It is demonstrated that inhibition of PI3K enhances NaBT-mediated cervical cancer cell apoptosis through the activation of the caspase pathway, and these findings will support future investigation using thePI3K inhibitors in combination with adjuvant treatment for treating carcinoma of the cervix.
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Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone
Dong-Ho Nam,Sabarish Ramachandran,Dae-Kyu Song,Kun-Young Kwon,Dong-Seok Jeon,So-Jin Shin,Sanghoon Kwon,Soon-Do Cha,Insoo Bae,Chi-Heum Cho +9 more
TL;DR: The results suggest that uterine leiomyomas growth and differentiation might be modulated through PPARGamma receptors and that PPARgamma ligands may be of potential use for uterineLeiomyoma treatment.
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The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.
Jonathan Kopel,Kei Higuchi,Bojana Ristic,Toshihiro Sato,Sabarish Ramachandran,Vadivel Ganapathy +5 more
TL;DR: A novel mechanism for the anti-diabetic actions of metformin is uncovered, which inhibits the expression of the plasma membrane citrate transporter NaCT in HepG2 cells and decreases cellular levels of citrate.
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Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer.
Yangzom D. Bhutia,Jiro Ogura,Paul J. Grippo,Carolina Torres,Toshihiro Sato,Mitchell S. Wachtel,Sabarish Ramachandran,Ellappan Babu,Sathish Sivaprakasam,Devaraja Rajasekaran,Bradley Schniers,Nhu On,Logan Smoot,Muthusamy Thangaraju,Jaya P. Gnana-Prakasam,Vadivel Ganapathy +15 more
TL;DR: In vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.
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Expression of apoptotic nuclei by ultrastructural terminal deoxyribonucleotidyl transferase mediated dUTP nick end labeling and detection of FasL, caspases and PARP protein molecules in cadmium induced acute alveolar cell injury
TL;DR: It is suggested that cadmium-induced alveolar cell apoptosis is mediated by FasL and caspase-dependent mitochondrial apoptosis pathways and detected related molecules in tissue of cadmity-induced acute lung injury.