S
Sabarish Ramachandran
Researcher at Texas Tech University Health Sciences Center
Publications - 46
Citations - 1780
Sabarish Ramachandran is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Cancer & Mammary tumor. The author has an hindex of 17, co-authored 41 publications receiving 1364 citations. Previous affiliations of Sabarish Ramachandran include Georgia Regents University & Keimyung University.
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Journal ArticleDOI
Identification of a novel Na + -coupled Fe 3+ -citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells.
Jiro Ogura,Ellappan Babu,Seiji Miyauchi,Sabarish Ramachandran,Elizebeta Nemeth,Yangzom D. Bhutia,Vadivel Ganapathy +6 more
TL;DR: A hitherto unknown transport system for citrate in mammalian cells that was detectable in primary hepatocytes and neuronal cell lines and has implications to iron-overload conditions where circulating free iron increases, which would stimulate cellular uptake of citrate and consequently affect multiple metabolic pathways.
Journal ArticleDOI
Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6)
TL;DR: The present review highlights the unusual involvement of selective amino acid transporters in macropinocytosis and diet-induced obesity/metabolic syndrome.
Proceedings ArticleDOI
Abstract 18: Slc5a8 inactivation is associated with mammary gland involution delay, early onset of mammary tumorigenesis and accelerated lung metastasis
Sabarish Ramachandran,Selvakumar Elangovan,Rajneesh Pathania,Puttur D. Prasad,Vadivel Ganapathy,Muthusamy Thangaraju +5 more
TL;DR: It is shown that milk stasis-associated mechanical stretching, which occurs in early onset of mammary gland involution, dramatically induced Slc5a8 expression in luminal epithelium and that induction of Slc 5a8 with DNA methyltransferase inhibitors coupled with butyrate administration might represent a novel approach to breast cancer treatment.
Journal ArticleDOI
Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer
Pulak R. Manna,Sabarish Ramachandran,Jangampalli Adi Pradeepkiran,Deborah Molehin,Isabel Castro-Piedras,Kevin Pruitt,Vadivel Ganapathy,P. Hemachandra Reddy +7 more
TL;DR: In this article , the authors demonstrate that StAR mRNA expression was aberrantly high in human hormone-dependent BC (MCF7, MDA-MB-361, and T-47D), modest in hormone-independent triple negative BC (TNBC), and had little to none in non-cancerous mammary epithelial (HMEC, MCF10A, and MCF12F) cells.
Journal ArticleDOI
Retraction Note: Identification of a novel Na + -coupled Fe 3+ -citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
Jiro Ogura,Ellappan Babu,Seiji Miyauchi,Sabarish Ramachandran,Elizebeta Nemeth,Yangzom D. Bhutia,Vadivel Ganapathy +6 more
TL;DR: This paper has been retracted at the request of the authors because of a lack of confidence in the ability of the reviewers to assess the reliability of the original data.