S
Saeed Eshtad
Researcher at Science for Life Laboratory
Publications - 9
Citations - 1551
Saeed Eshtad is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Cancer & DNA repair. The author has an hindex of 6, co-authored 8 publications receiving 1300 citations. Previous affiliations of Saeed Eshtad include Karolinska Institutet.
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Journal ArticleDOI
Mechanisms underlying mutational signatures in human cancers
TL;DR: Mutational signatures can be used as a physiological readout of the biological history of a cancer and also have potential use for discerning ongoing mutational processes from historical ones, thus possibly revealing new targets for anticancer therapies.
Journal ArticleDOI
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Helge Gad,Tobias Koolmeister,Ann-Sofie Jemth,Saeed Eshtad,Sylvain A. Jacques,Cecilia E. Ström,Linda M. Svensson,Niklas Schultz,Thomas Lundbäck,Berglind Osk Einarsdottir,Aljona Saleh,Camilla Göktürk,Pawel Baranczewski,Richard Svensson,Ronnie P.-A. Berntsson,Robert Gustafsson,Kia Strömberg,Kumar Sanjiv,Marie-Caroline Jacques-Cordonnier,Matthieu Desroses,Anna-Lena Gustavsson,Roger Olofsson,Fredrik Johansson,Evert Homan,Olga Loseva,Lars Bräutigam,Lars Johansson,Andreas Höglund,Anna Hagenkort,Therese Pham,Mikael Altun,Fabienne Z. Gaugaz,Svante Vikingsson,Bastiaan Evers,Martin Henriksson,Karl S. A. Vallin,Olov A. Wallner,Lars Hammarström,Elisee Wiita,Ingrid Almlöf,Christina Kalderén,Hanna Axelsson,Tatjana Djureinovic,Jordi Carreras Puigvert,Maria Häggblad,Fredrik Jeppsson,Ulf Martens,Cecilia Lundin,Bo Lundgren,Ingrid Granelli,Annika Jenmalm Jensen,Per Artursson,Jonas Nilsson,Pål Stenmark,Martin Scobie,Ulrika Warpman Berglund,Thomas Helleday +56 more
TL;DR: This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool - Supporting Information
Helge Gad,Tobias Koolmeister,Ann-Sofie Jemth,Saeed Eshtad,Sylvain A. Jacques,Cecilia E. Ström,Linda M. Svensson,Niklas Schultz,Thomas Lundbäck,Berglind Osk Einarsdottir,Aljona Saleh,Camilla Göktürk,Pawel Baranczewski,Richard Svensson,Ronnie P.-A. Berntsson,Robert Gustafsson,Kia Strömberg,Kumar Sanjiv,Marie-Caroline Jacques-Cordonnier,Matthieu Desroses,Anna-Lena Gustavsson,Roger Olofsson,Fredrik Johansson,Evert Homan,Olga Loseva,Lars Hammarström +25 more
TL;DR: In this paper, the authors validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH 1 protein in cells.
Journal ArticleDOI
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Torkild Visnes,Torkild Visnes,Carlos Benitez-Buelga,Armando Cázares-Körner,Kumar Sanjiv,Bishoy M. F. Hanna,Oliver Mortusewicz,Varshni Rajagopal,Julian J Albers,Daniel W. Hagey,Tove Bekkhus,Saeed Eshtad,Juan Miguel Baquero,Geoffrey Masuyer,Geoffrey Masuyer,Olov A. Wallner,Sarah Müller,Therese Pham,Camilla Göktürk,Azita Rasti,Sharda Suman,Raúl Torres-Ruiz,Antonio Sarno,Antonio Sarno,Elisee Wiita,Evert Homan,Stella Karsten,Karthick Marimuthu,Maurice Michel,Tobias Koolmeister,Martin Scobie,Olga Loseva,Ingrid Almlöf,Judith E. Unterlass,Aleksandra Pettke,Johan Boström,Monica Pandey,Helge Gad,Patrick Herr,Ann-Sofie Jemth,Samir El Andaloussi,Christina Kalderén,Sandra Rodriguez-Perales,Javier Benitez,Hans E. Krokan,Mikael Altun,Pål Stenmark,Pål Stenmark,Ulrika Warpman Berglund,Thomas Helleday,Thomas Helleday +50 more
TL;DR: OGG1 depletion obstructs A3 T-cell lymphoblastic acute leukemia growth in vitro and in vivo, validating OGG1 as a potential anti-cancer target and showing that O GG1 inhibitors (OGG1i) target a wide range of cancer cells, with a favourable therapeutic index compared to non-transformed cells.
Journal ArticleDOI
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Saeed Eshtad,Z Mavajian,Sean G. Rudd,Torkild Visnes,Johan Boström,Mikael Altun,Thomas Helleday +6 more
TL;DR: The results suggest that hMYH and hMTH1 functionally cooperate for effective repair and survival in mismatch repair defective T-ALL Jurkat A3 cells.