R
Ronnie P.-A. Berntsson
Researcher at Umeå University
Publications - 47
Citations - 2482
Ronnie P.-A. Berntsson is an academic researcher from Umeå University. The author has contributed to research in topics: Peptide binding & Gene. The author has an hindex of 21, co-authored 42 publications receiving 2110 citations. Previous affiliations of Ronnie P.-A. Berntsson include Stockholm University & University of Groningen.
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Journal ArticleDOI
A structural classification of substrate-binding proteins
TL;DR: This work proposes a new classification into six clusters of substrate‐binding proteins, based on features of their three‐dimensional structure, and divides these proteins into three structural classes and two functional classes.
Journal ArticleDOI
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Helge Gad,Tobias Koolmeister,Ann-Sofie Jemth,Saeed Eshtad,Sylvain A. Jacques,Cecilia E. Ström,Linda M. Svensson,Niklas Schultz,Thomas Lundbäck,Berglind Osk Einarsdottir,Aljona Saleh,Camilla Göktürk,Pawel Baranczewski,Richard Svensson,Ronnie P.-A. Berntsson,Robert Gustafsson,Kia Strömberg,Kumar Sanjiv,Marie-Caroline Jacques-Cordonnier,Matthieu Desroses,Anna-Lena Gustavsson,Roger Olofsson,Fredrik Johansson,Evert Homan,Olga Loseva,Lars Bräutigam,Lars Johansson,Andreas Höglund,Anna Hagenkort,Therese Pham,Mikael Altun,Fabienne Z. Gaugaz,Svante Vikingsson,Bastiaan Evers,Martin Henriksson,Karl S. A. Vallin,Olov A. Wallner,Lars Hammarström,Elisee Wiita,Ingrid Almlöf,Christina Kalderén,Hanna Axelsson,Tatjana Djureinovic,Jordi Carreras Puigvert,Maria Häggblad,Fredrik Jeppsson,Ulf Martens,Cecilia Lundin,Bo Lundgren,Ingrid Granelli,Annika Jenmalm Jensen,Per Artursson,Jonas Nilsson,Pål Stenmark,Martin Scobie,Ulrika Warpman Berglund,Thomas Helleday +56 more
TL;DR: This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool - Supporting Information
Helge Gad,Tobias Koolmeister,Ann-Sofie Jemth,Saeed Eshtad,Sylvain A. Jacques,Cecilia E. Ström,Linda M. Svensson,Niklas Schultz,Thomas Lundbäck,Berglind Osk Einarsdottir,Aljona Saleh,Camilla Göktürk,Pawel Baranczewski,Richard Svensson,Ronnie P.-A. Berntsson,Robert Gustafsson,Kia Strömberg,Kumar Sanjiv,Marie-Caroline Jacques-Cordonnier,Matthieu Desroses,Anna-Lena Gustavsson,Roger Olofsson,Fredrik Johansson,Evert Homan,Olga Loseva,Lars Hammarström +25 more
TL;DR: In this paper, the authors validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH 1 protein in cells.
Journal ArticleDOI
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Jordi Carreras-Puigvert,Marinka Zitnik,Marinka Zitnik,Ann-Sofie Jemth,Megan Carter,Judith E. Unterlass,Björn M. Hallström,Olga Loseva,Zhir Karem,José Manuel Calderón-Montaño,Cecilia Lindskog,Per-Henrik Edqvist,Damian J. Matuszewski,Hammou Ait Blal,Ronnie P.-A. Berntsson,Maria Häggblad,Ulf Martens,Matthew Studham,Bo Lundgren,Carolina Wählby,Erik L. L. Sonnhammer,Emma Lundberg,Pål Stenmark,Blaz Zupan,Blaz Zupan,Thomas Helleday +25 more
TL;DR: A comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to address their functional inter-relationships, which will prove fundamental to understanding their biological functionality.
Journal ArticleDOI
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins
Lisheng Peng,Ronnie P.-A. Berntsson,William H. Tepp,Rose M. Pitkin,Eric A. Johnson,Pål Stenmark,Min Dong +6 more
TL;DR: It is reported that a mosaic toxin, type D-C (BoNT/D-C), uses different receptors from its parental toxin BoNT/C, and SytI/II, in conjunction with gangliosides, are established as the receptors for BoNT/.