Antonio Sarno

TL;DR: Although TP53 mutations and 17p deletions are found in a high proportion of F-refractory CLL, more than half of the cases cannot be explained by p53 defects (deletion or mutation), and alternative mechanisms need to be investigated.

TL;DR: A small-molecule drug that acts as a potent and selective active-site inhibitor that stops OGG1 from recognizing its DNA substrate and hampers Ogg1 binding to and repair of 8-oxoG is developed, which is well tolerated by mice and presents a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo.

TL;DR: A range of molecular degradation products were identified in seawater leachates after UV exposure, with increasing abundance over the duration of the experiment, and a variety of additive chemicals were shown to leach from the MFs into seawater.

TL;DR: Evidence from mass spectrometric quantitation of deoxyuridine in DNA that shows significantly higher genomic uracil content in B-cell lymphoma cell lines compared to non-lymphoma cancer cell lines and normal circulating lymphocytes is presented, indicating that AID-induced mutagenic U:G mismatches in DNA may be a fundamental and common cause of mutations inB-cell malignancies.

TL;DR: Changes in cellular processes and pathways not previously associated with melphalan resistance in multiple myeloma cells are discovered, including a metabolic switch conforming to the Warburg effect (aerobic glycolysis), and an elevated oxidative stress response mediated by VEGF/IL8-signaling.