P
Pritha Sen
Researcher at Harvard University
Publications - 23
Citations - 2744
Pritha Sen is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 11, co-authored 20 publications receiving 1379 citations. Previous affiliations of Pritha Sen include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Efficacy of Tocilizumab in Patients Hospitalized with Covid-19.
John H. Stone,Matthew J. Frigault,Naomi Serling-Boyd,Ana D. Fernandes,Liam Harvey,Andrea S. Foulkes,Nora Horick,Brian C. Healy,Ruta Shah,Ana Maria Bensaci,Ann E. Woolley,Sarah Nikiforow,Nina Lin,Manish Sagar,Harry M Schrager,David S. Huckins,Matthew Axelrod,Michael D. Pincus,Jorge Fleisher,Chana A. Sacks,Michael Dougan,Crystal M. North,Yuan Di C. Halvorsen,Tara K. Thurber,Zeina Dagher,Allison K. Scherer,Rachel Wallwork,Arthur Y. Kim,Sara R. Schoenfeld,Pritha Sen,Tomas G. Neilan,Cory A. Perugino,Sebastian Unizony,Deborah S. Collier,Mark Matza,Janeth Yinh,Kathryn Bowman,Eric A. Meyerowitz,Amna Zafar,Zsofia D. Drobni,Marcy B. Bolster,Minna J. Kohler,Kristin M. D’Silva,Jonathan Dau,Megan Lockwood,Caroline Cubbison,Brittany Weber,Michael K. Mansour +47 more
TL;DR: Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19, and some benefit or harm cannot be ruled out, however, because the confidence intervals for efficacy comparisons were wide.
Journal ArticleDOI
Microglia in neurodegeneration.
TL;DR: The immune checkpoints that control microglial functions are considered and how their imbalance and subsequent neuroinflammation leads to neurodegeneration is discussed.
Journal ArticleDOI
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.
Toni Delorey,Carly G. K. Ziegler,Graham Heimberg,Rachelly Normand,Yiming Yang,Yiming Yang,Asa Segerstolpe,Domenic Abbondanza,Stephen J. Fleming,Ayshwarya Subramanian,Daniel T. Montoro,Karthik A. Jagadeesh,Kushal K. Dey,Pritha Sen,Michal Slyper,Yered Pita-Juárez,Devan Phillips,Jana Biermann,Zohar Bloom-Ackermann,Nikolaos Barkas,Andrea Ganna,Andrea Ganna,James Gomez,Johannes C. Melms,Igor Katsyv,Erica Normandin,Erica Normandin,Pourya Naderi,Pourya Naderi,Yury Popov,Yury Popov,Siddharth S. Raju,Siddharth S. Raju,Sebastian Niezen,Sebastian Niezen,Linus T.-Y. Tsai,Katherine J. Siddle,Katherine J. Siddle,Malika Sud,Victoria M. Tran,Shamsudheen K. Vellarikkal,Shamsudheen K. Vellarikkal,Yiping Wang,Liat Amir-Zilberstein,Deepak Atri,Deepak Atri,Joseph M. Beechem,Olga R. Brook,Jonathan H. Chen,Jonathan H. Chen,Prajan Divakar,Phylicia Dorceus,Jesse M. Engreitz,Jesse M. Engreitz,Adam Essene,Donna M. Fitzgerald,Robin Fropf,Steven Gazal,Joshua Gould,John Grzyb,Tyler Harvey,Jonathan L. Hecht,Jonathan L. Hecht,Tyler Hether,Judit Jané-Valbuena,Michael Leney-Greene,Hui Ma,Hui Ma,Cristin McCabe,Daniel E. McLoughlin,Eric M. Miller,Christoph Muus,Christoph Muus,Mari Niemi,Robert F. Padera,Robert F. Padera,Robert F. Padera,Liuliu Pan,Deepti Pant,Carmel Pe’er,Jenna Pfiffner-Borges,Christopher J. Pinto,Jacob Plaisted,Jason Reeves,Marty Ross,Melissa Rudy,Erroll H. Rueckert,Michelle Siciliano,Alexander Sturm,Ellen Todres,Avinash Waghray,Sarah Warren,Shuting Zhang,Daniel R. Zollinger,Lisa A. Cosimi,Rajat M. Gupta,Rajat M. Gupta,Nir Hacohen,Nir Hacohen,Hanina Hibshoosh,Winston Hide,Alkes L. Price,Jayaraj Rajagopal,Purushothama Rao Tata,Stefan Riedel,Stefan Riedel,Gyongyi Szabo,Gyongyi Szabo,Gyongyi Szabo,Timothy L. Tickle,Patrick T. Ellinor,Deborah T. Hung,Deborah T. Hung,Pardis C. Sabeti,Richard M. Novak,Robert S. Rogers,Robert S. Rogers,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Z. Gordon Jiang,Z. Gordon Jiang,Dejan Juric,Mehrtash Babadi,Samouil L. Farhi,Benjamin Izar,James R. Stone,Ioannis S. Vlachos,Isaac H. Solomon,Orr Ashenberg,Caroline B. M. Porter,Bo Li,Bo Li,Alex K. Shalek,Alexandra-Chloé Villani,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Aviv Regev +137 more
TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.
Journal ArticleDOI
Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19.
Richard M. Burwick,Sigal Yawetz,Sigal Yawetz,Kathryn E. Stephenson,Kathryn E. Stephenson,Ai-ris Y. Collier,Ai-ris Y. Collier,Pritha Sen,Brian G. Blackburn,E Milunka Kojic,Adi Hirshberg,Jose F. Suarez,Magdalena E. Sobieszczyk,Kristen M. Marks,Shawn Mazur,Cecilia Big,Oriol Manuel,Gregory Morlin,Suzanne J Rose,Mariam Naqvi,Ilona T. Goldfarb,Adam DeZure,Laura Telep,Susanna K Tan,Yang Zhao,Tom Hahambis,Jason Hindman,Anand P Chokkalingam,Christoph C Carter,Moupali Das,Anu Osinusi,Diana M. Brainard,Tilly A. Varughese,Olga A. Kovalenko,Matthew D Sims,Samit Desai,Geeta K. Swamy,Jeanne S. Sheffield,Rebecca Zash,Rebecca Zash,William R. Short +40 more
TL;DR: Among 86 pregnant and postpartum women with severe COVID-19 who received compassionate-use remdesivir, recovery rates were high, with a low rate of serious AEs.
Journal ArticleDOI
Glioblastoma hijacks microglial gene expression to support tumor growth.
Sybren L. N. Maas,Sybren L. N. Maas,Erik R. Abels,Lieke L. Van De Haar,Xuan Zhang,Liza M. Morsett,Srinjoy Sil,Joana R. Guedes,Joana R. Guedes,Pritha Sen,Shilpa Prabhakar,Suzanne E. Hickman,Charles P. Lai,Charles P. Lai,David T. Ting,Xandra O. Breakefield,Marike L. D. Broekman,Marike L. D. Broekman,Joseph El Khoury +18 more
TL;DR: A microglia Glioblastoma specific phenotype is defined, whereby gliOBlastomas have hijacked gene expression in the neuroimmune system to favor avoiding tumor sensing, suppressing the immune response, clearing a path for invasion, and enhancing tumor propagation.