Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift.
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TLDR
A new paradigm to study innate immune cells following TBI is proposed that moves away from the existing M1/M2 classification of activation states toward a stimulus- and disease-specific understanding of polarization state based on transcriptomic and proteomic profiling.About:
This article is published in Neuron.The article was published on 2017-09-13 and is currently open access. It has received 450 citations till now. The article focuses on the topics: Neuroimmunology & Traumatic brain injury.read more
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Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner
Emily F. Willis,Kelli P. A. MacDonald,Quan Nguyen,Adahir Labrador Garrido,Ellen R. Gillespie,Samuel B. R. Harley,Perry F. Bartlett,Wayne A. Schroder,Wayne A. Schroder,Abi G. Yates,Daniel C. Anthony,Stefan Rose-John,Marc J. Ruitenberg,Jana Vukovic +13 more
TL;DR: It is concluded that microglia in the mammalian brain can be manipulated to adopt a neuroprotective and pro-regenerative phenotype that can aid repair and alleviate the cognitive deficits arising from brain injury.
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
Terry K. Means,Terry K. Means,Eleftherios Mylonakis,Emmanouil Tampakakis,Richard A. Colvin,Edward Seung,Lindsay Puckett,Melissa F. Tai,Cameron R. Stewart,Read Pukkila-Worley,Suzanne E. Hickman,Kathryn J. Moore,Stephen B. Calderwood,Nir Hacohen,Nir Hacohen,Andrew D. Luster,Joseph El Khoury +16 more
TL;DR: CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
Journal ArticleDOI
Pathophysiology and treatment of cerebral edema in traumatic brain injury.
TL;DR: A translational synopsis of present and future strategies targeting CE after TBI in the context of a paradigm shift towards precision medicine is provided.
Journal ArticleDOI
The anatomy and immunology of vasculature in the central nervous system.
TL;DR: An overview of cerebrovascular anatomy is provided, focusing on the blood-CNS interface and how anatomical variations influence steady-state immunology in the compartment, and how CNS vasculature is affected by and influences the development of different pathophysiological states.
Journal ArticleDOI
MicroRNAs in Neuroinflammation: Implications in Disease Pathogenesis, Biomarker Discovery and Therapeutic Applications.
TL;DR: The aim of this review is to summarize the mode of regulation for several important and well-studied microRNAs in the context of neuroinflammation, includingmiR-155, miR-146a, miM-124,MiR-21 and let-7, and the pathological consequences of miRNA deregulation during disorders that feature neuro inflammation are discussed.
References
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