S
Saïd Bendahhou
Researcher at Centre national de la recherche scientifique
Publications - 55
Citations - 6687
Saïd Bendahhou is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Periodic paralysis & Potassium channel. The author has an hindex of 29, co-authored 50 publications receiving 6332 citations. Previous affiliations of Saïd Bendahhou include University of Nice Sophia Antipolis & University of Utah.
Papers
More filters
Journal ArticleDOI
KCNQ1 gain-of-function mutation in familial atrial fibrillation
Yi-Han Chen,Shi-Jie Xu,Shi-Jie Xu,Saïd Bendahhou,Xiao-Liang Wang,Ying Wang,Wenyuan Xu,Hong-Wei Jin,Hao Sun,Xiaoyan Su,Qi-Nan Zhuang,Yiqing Yang,Yue-Bin Li,Yi Liu,Hong-Ju Xu,Xiao-Fei Li,Ning Ma,Chun-Ping Mou,Zhu Chen,Jacques Barhanin,Wei Huang,Wei Huang +21 more
TL;DR: Functional analysis of the S140G mutant revealed a gain-of-function effect on the KCNQ1/KCNE1 and theKCNQ 1/ KCNE2 currents, which contrasts with the dominant negative or loss-of -function effects of the KCnQ1 mutations previously identified in patients with long QT syndrome.
Journal ArticleDOI
Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
Nikki M. Plaster,Rabi Tawil,Martin Tristani-Firouzi,Sonia Canún,Saïd Bendahhou,Akiko Tsunoda,Matthew R. Donaldson,Susan T. Iannaccone,Ewout R. Brunt,Richard J. Barohn,Richard J. Barohn,John Wesley Clark,Feza Deymeer,Alfred L. George,Frank A. Fish,Angelika F. Hahn,Alexandru Nitu,Coşkun Özdemir,Piraye Serdaroglu,S. H. Subramony,Gil I. Wolfe,Ying-Hui Fu,Louis J. Ptáček +22 more
TL;DR: In this paper, the authors have mapped an Andersen's locus to chromosome 17q23 near the inward rectifying potassium channel gene KCNJ2.1, which was found to play an important role in developmental signaling.
Journal Article
Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's Syndrome
Nikki M. Plaster,Rabi Tawil,Martin Tristani-Firouzi,Sonia Canún,Saïd Bendahhou,A Soemori,Donaldson,Susan T. Iannaccone,Ewout R. Brunt,Richard J. Barohn,J Clark,Feza Deymeer,Alfred L. George,Angelika F. Hahn,A Nitu,Piraye Serdaroglu,S. H. Subramony,Gil I. Wolfe,Ying-Hui Fu,Louis J. Ptáček +19 more
TL;DR: Findings suggest that Kir2.1 plays an important role in developmental signaling in addition to its previously recognized function in controlling cell excitability in skeletal muscle and heart.
Journal ArticleDOI
Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome)
Martin Tristani-Firouzi,Judy L. Jensen,Matthew R. Donaldson,Valeria A. Sansone,Giovanni Meola,Angelika Hahn,Saïd Bendahhou,Hubert Kwieciński,Anna Fidziańska,Nikki M. Plaster,Ying-Hui Fu,Louis J. Ptáček,Rabi Tawil +12 more
TL;DR: The functional consequences of three novel and seven previously described KCNJ2 mutations using a two-microelectrode voltage-clamp technique and correlated the findings with the clinical phenotype suggest that the substrate for arrhythmia susceptibility in AS is distinct from the other forms of inherited LQT syndrome.
Journal ArticleDOI
Identification of a KCNE2 Gain-of-Function Mutation in Patients with Familial Atrial Fibrillation
Yiqing Yang,Min Xia,Qingfeng Jin,Saïd Bendahhou,Jingyi Shi,Yiping Chen,Bo Liang,Jie Lin,Yi Liu,Ban Liu,Qinshu Zhou,Dongwei Zhang,Rong Wang,Ning Ma,Xiaoyan Su,Kaiya Niu,Yan Pei,Wenyuan Xu,Zhaopeng Chen,Haiying Wan,Jianmin Cui,Jacques Barhanin,Yi-Han Chen +22 more
TL;DR: The evaluation of 28 unrelated Chinese kindreds with AF found an arginine-to-cysteine mutation at position 27 (R27C) of KCNE2, the beta subunit of the KCNQ1-KCNE2 channel responsible for a background potassium current, is a gain-of-function mutation associated with the initiation and/or maintenance of AF.