Journal ArticleDOI
KCNQ1 gain-of-function mutation in familial atrial fibrillation
Yi-Han Chen,Shi-Jie Xu,Shi-Jie Xu,Saïd Bendahhou,Xiao-Liang Wang,Ying Wang,Wenyuan Xu,Hong-Wei Jin,Hao Sun,Xiaoyan Su,Qi-Nan Zhuang,Yiqing Yang,Yue-Bin Li,Yi Liu,Hong-Ju Xu,Xiao-Fei Li,Ning Ma,Chun-Ping Mou,Zhu Chen,Jacques Barhanin,Wei Huang,Wei Huang +21 more
TLDR
Functional analysis of the S140G mutant revealed a gain-of-function effect on the KCNQ1/KCNE1 and theKCNQ 1/ KCNE2 currents, which contrasts with the dominant negative or loss-of -function effects of the KCnQ1 mutations previously identified in patients with long QT syndrome.Abstract:
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel (KCNQ1/KCNE1), the KCNQ1/KCNE2 and the KCNQ1/KCNE3 potassium channels. Functional analysis of the S140G mutant revealed a gain-of-function effect on the KCNQ1/KCNE1 and the KCNQ1/KCNE2 currents, which contrasts with the dominant negative or loss-of-function effects of the KCNQ1 mutations previously identified in patients with long QT syndrome. Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes.read more
Citations
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Journal ArticleDOI
Guidelines for the management of atrial fibrillation The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
A. John Camm,Paulus Kirchhof,Irene Savelieva,Isabelle C. Van Gelder,Gerhard Hindricks,Ottavio Alfieri,Johan De Sutter,Andreas Goette,Stefan H. Hohloser,Piotr Ponikowski,Frans H. Rutten +10 more
TL;DR: Estimates of expected health outcomes for larger societies are included, where data exist, and the level of evidence and the strength of recommendation of particular treatment options are weighed and graded according to pre-defined scales.
Journal ArticleDOI
Guidelines for the management of atrial fibrillation
A. John Camm,Paulus Kirchhof,Gregory Lip,Ulrich Schotten,Irene Savelieva,Sabine Ernst,Isabelle C. Van Gelder,Nawwar Al-Attar,Gerhard Hindricks,Bernard Prendergast,Hein Heidbuchel,Ottavio Alfieri,Annalisa Angelini,Dan Atar,Paolo Colonna,Raffaele De Caterina,Johan De Sutter,Andreas Goette,Bulent Gorenek,Magnus Heldal,Stefan H. Hohloser,Philippe Kolh,Jean-Yves Le Heuzey,Piotr Ponikowski,Frans H. Rutten,Alec Vahanian,Angelo Auricchio,Jeroen J. Bax,Claudio Ceconi,Veronica Dean,Gerasimos Filippatos,Christian Funck-Brentano,Richard Hobbs,Peter Kearney,Theresa McDonagh,Bogdan A. Popescu,Zeljko Reiner,Udo Sechtem,Per Anton Sirnes,Michal Tendera,Panos E. Vardas,Petr Widimsky,Vazha Agladze,Etienne Aliot,Tosho L. Balabanski,Carina Blomström-Lundqvist,Alessandro Capucci,Harry J.G.M. Crijns,Björn Dahlöf,Thierry Folliguet,Michael Glikson,Marnix Goethals,Dietrich C. Gulba,Siew Yen Ho,Robert J.M. Klautz,Sedat Kose,John McMurray,Pasquale Perrone Filardi,Pekka Raatikainen,Maria Jesus Salvador,Martin J. Schalij,Alexander Shpektor,João de Sousa,Janina Stepinska,Hasso Uuetoa,José Luis Zamorano,Igor Zupan +66 more
TL;DR: Guidelines summarize and evaluate all currently available evidence on a particular issue with the aim of assisting physicians in selecting the best management strategy for an individual patient suffering from a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means.
Journal ArticleDOI
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Hugh Calkins,Karl-Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Younghoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,Niv Ad,Jennifer E. Cummings,A. Mark Gillinov,Hein Heidbuchel,Craig T. January,Gregory Y.H. Lip,Steven M. Markowitz,Mohan Nair,I. Eli Ovsyshcher,Hui Nam Pak,Takeshi Tsuchiya,Dipen Shah,Teo Wee Siong,Panos E. Vardas +60 more
TL;DR: This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure.
Journal ArticleDOI
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
Valentin Fuster,Lars Rydén,David S. Cannom,Harry J.G.M. Crijns,Anne B. Curtis,Kenneth A. Ellenbogen,Jonathan L. Halperin,Jean-Yves Le Heuzey,G. Neal Kay,James E. Lowe,S. Bertil Olsson,Eric N. Prystowsky,Juan Tamargo,Samuel Wann,Sidney C. Smith,Alice K. Jacobs,Cynthia D. Adams,Jeffery L. Anderson,Elliott M. Antman,Sharon A. Hunt,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel,Silvia G. Priori,Jean Jacques Blanc,Andrzej Budaj,A. John Camm,Veronica Dean,Jaap W. Deckers,Catherine Despres,Kenneth Dickstein,John Lekakis,Keith McGregor,Marco Metra,João Morais,Ady Osterspey,José Luis Zamorano +37 more
TL;DR: Sidney C. Smith, Jr., MD, FACC, FAHA, FESC, Chair; Alice K. Jacobs, MD, FAC, FAH, Vice-Chair; Cynthia D. Adams, MSN, APRN-BC, FAGA; Jeffery L. Anderson, MD.
Journal ArticleDOI
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study.
Donald M. Lloyd-Jones,Thomas J. Wang,Thomas J. Wang,Eric P. Leip,Eric P. Leip,Martin G. Larson,Martin G. Larson,Daniel Levy,Daniel Levy,Ramachandran S. Vasan,Ramachandran S. Vasan,Ralph B. D'Agostino,Ralph B. D'Agostino,Joseph M. Massaro,Joseph M. Massaro,Alexa S. Beiser,Alexa S. Beiser,Philip A. Wolf,Philip A. Wolf,Philip A. Wolf,Emelia J. Benjamin,Emelia J. Benjamin +21 more
TL;DR: Lifetime risks for development of AF are 1 in 4 for men and women 40 years of age and older, even in the absence of antecedent congestive heart failure or myocardial infarction, and substantial lifetime risks underscore the major public health burden posed by AF.
References
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Journal ArticleDOI
Prevalence, Age Distribution, and Gender of Patients With Atrial Fibrillation: Analysis and Implications
TL;DR: The prevalence of atrial fibrillation (AF) is related to age, and the risk of hemorrhage may be increased in older patients as mentioned in this paper, however, the age and gender-specific prevalence of AF is not known.
Prevalence, Age Distribution, and Gender of Patients With Atrial Fibrillation
TL;DR: The risks and benefits of antithrombotic therapy in older individuals are important considerations in stroke prevention in atrial fibrillation patients.
Journal ArticleDOI
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Qiuyun Chen,Glenn E. Kirsch,Danmei Zhang,Ramon Brugada,Josep Brugada,Pedro Brugada,Domenico Potenza,Angel Moya,Martin Borggrefe,Günter Breithardt,Rocio Ortiz-Lopez,Zhiqing Wang,Charles Antzelevitch,Richard E. O'Brien,Eric Schulze-Bahr,Mark T. Keating,Jeffrey A. Towbin,Qing Wang +17 more
TL;DR: It is shown that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional.
Journal ArticleDOI
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Qing Wang,Mark E. Curran,Igor Splawski,Timothy C. Burn,J. M. Millholland,T. J. VanRaay,Jiaxiang Shen,Katherine W. Timothy,Vincent Gm,Vincent Gm,T. De Jager,Peter J. Schwartz,J.A. Towbin,Arthur J. Moss,Donald L. Atkinson,Gregory M. Landes,Timothy D. Connors,M T Keating +17 more
TL;DR: In this article, positional cloning was used to establish KVLQT1 as the chromosome 11-linked LQT 1 gene responsible for the most common inherited cardiac arrhythmia.
Journal ArticleDOI
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Michael C. Sanguinetti,Mark E. Curran,Anruo Zou,Jiaxiang Shen,Peter S. Spector,Donald L. Atkinson,M T Keating +6 more
TL;DR: KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia, and is shown to encode a K+ channel with biophysical properties unlike other known cardiac currents.
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