Yi Liu

TL;DR: Functional analysis of the S140G mutant revealed a gain-of-function effect on the KCNQ1/KCNE1 and theKCNQ 1/ KCNE2 currents, which contrasts with the dominant negative or loss-of -function effects of the KCnQ1 mutations previously identified in patients with long QT syndrome.

TL;DR: The evaluation of 28 unrelated Chinese kindreds with AF found an arginine-to-cysteine mutation at position 27 (R27C) of KCNE2, the beta subunit of the KCNQ1-KCNE2 channel responsible for a background potassium current, is a gain-of-function mutation associated with the initiation and/or maintenance of AF.

TL;DR: The inward rectifier K(+) channel Kir2.1 mediates the potassium I(K1) current in the heart and a valine-to-isoleucine mutation at position 93 (V93I) of Kir1.1 was found in all affected members in one kindred.

TL;DR: The findings suggest a role for Kir3.4 in the etiology of LQTS, a hereditary disorder that leads to sudden cardiac death secondary to fatal cardiac arrhythmias in a large Chinese family with autosomal-dominant LQ TS.

TL;DR: The findings indicated that plasma miR-134 could be an important biomarker for the diagnosis of APE, and large-scale investigations are urgently needed to pave the way from basic research to clinical utilization.