S
Saijun Fan
Researcher at Peking Union Medical College
Publications - 95
Citations - 4240
Saijun Fan is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Apoptosis & Total body irradiation. The author has an hindex of 28, co-authored 95 publications receiving 3235 citations. Previous affiliations of Saijun Fan include Soochow University (Suzhou) & Georgetown University.
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Journal ArticleDOI
The in Vitro and in Vivo Toxicity of Graphene Quantum Dots
Yu Chong,Yufei Ma,He Shen,Xiaolong Tu,Xuan Zhou,Jiaying Xu,Jianwu Dai,Saijun Fan,Zhijun Zhang +8 more
TL;DR: GQD possesses no obvious in vitro and in vivo toxicity, even under multi-dosing situation, as well as wide chemical adaptability and high adsorption capacity.
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In vivo renal clearance, biodistribution, toxicity of gold nanoclusters
TL;DR: Findings show that the GSH-protected gold nanoclusters have small size and can be metabolized by renal clearance and thus the toxicity can be significantly decreased.
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Ultrasmall Au(10-12)(SG)(10-12) nanomolecules for high tumor specificity and cancer radiotherapy.
Xiaodong Zhang,Zhentao Luo,Jie Chen,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Saijun Fan,Feiyue Fan,David Tai Leong,Jianping Xie +9 more
TL;DR: In this paper, a new class of radiosensitizers, which contain several gold atoms embedded inside a peptide shell (e.g., Au10-12 (SG) 10-12 ) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
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Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy
Xiaodong Zhang,Jie Chen,Zhentao Luo,Di Wu,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Pei-Xun Liu,Jing Zhao,Shuaidong Huo,Saijun Fan,Feiyue Fan,Xing-Jie Liang,Jianping Xie +13 more
TL;DR: A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH).
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Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.
Guoqian Chen,Jianhua Li,Mahendar Ochani,Beatriz Rendon-Mitchell,Xiaoling Qiang,Seenu Susarla,Luis Ulloa,Huan Yang,Saijun Fan,Sanna M. Goyert,Ping Wang,Kevin J. Tracey,Andrew E. Sama,Haichao Wang +13 more
TL;DR: It is demonstrated that genetic disruption of CD14 expression abrogated LPS‐induced TNF production but only partially attenuated LPS •HMGB1 release in cultures of primary murine peritoneal macrophages, suggesting that LPS stimulates macrophage to release HMGB1 partly through CD14‐ and TNF‐dependent mechanisms.