Sajedeh Eftekhari

TL;DR: The results indicate, for the first time, the possibility of CGRP signaling in the human trigeminal ganglion involving both neurons and satellite glial cells, and suggests a possible site of action for the novel C GRP receptor antagonists in migraine therapy.

TL;DR: CGRP receptor binding sites and expression of the C GRP receptor in rhesus and rat TG are demonstrated and the expression pattern of PACAP and glutamate suggests a possible interaction between the glutamatergic and CGRP system.

TL;DR: The data suggest that CGRP is expressed in C-fibers and may act on A-fiberers, rodent mast cells, and vascular smooth muscle cells that express the C GRP receptor, which represent potential pathophysiological targets of novel antimigraine agents such as the newly developed CGRp receptor antagonists.

TL;DR: This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system in a condition in need of new treatments.

TL;DR: This study demonstrates the detailed expression of C GRP and its receptor components within STN in the brainstem and in the spinal cord at C1-level, and shows the possibility of CGRP acting postjunctionally in these areas putatively involved in primary headaches.