M
Muhammad A. Jamaluddin
Researcher at University of Auckland
Publications - 6
Citations - 300
Muhammad A. Jamaluddin is an academic researcher from University of Auckland. The author has contributed to research in topics: Calcitonin gene-related peptide & Receptor. The author has an hindex of 4, co-authored 5 publications receiving 231 citations.
Papers
More filters
Journal ArticleDOI
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
Christopher S. Walker,Sajedeh Eftekhari,Rebekah L. Bower,Andrea Wilderman,Paul A. Insel,Lars Edvinsson,Henry J. Waldvogel,Muhammad A. Jamaluddin,Andrew F. Russo,Debbie L. Hay +9 more
TL;DR: This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system in a condition in need of new treatments.
Journal ArticleDOI
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M. Booe,Christopher S. Walker,James Barwell,Gabriel Kuteyi,John Simms,Muhammad A. Jamaluddin,Margaret L. Warner,Roslyn M. Bill,Paul W. R. Harris,Margaret A. Brimble,David R. Poyner,Debbie L. Hay,Augen A. Pioszak +12 more
TL;DR: The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.
Journal ArticleDOI
Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist.
Elyse T. Williams,Paul W. R. Harris,Muhammad A. Jamaluddin,Kerry M. Loomes,Debbie L. Hay,Margaret A. Brimble +5 more
TL;DR: To showcase the utility of SP-CLipPA, a potent calcitonin gene-related peptide (CGRP) receptor antagonist peptide is synthesized in excellent yield and purity and has potential for the treatment of migraine.
Journal ArticleDOI
Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.
Erica R. Hendrikse,Lydia P. Liew,Rebekah L. Bower,Muriel Bonnet,Muhammad A. Jamaluddin,Nicole Prodan,Keith Richards,Christopher S. Walker,Garry Pairaudeau,David M. Smith,Roxana Maria Rujan,Risha Sudra,Christopher A. Reynolds,Jason M. Booe,Augen A. Pioszak,Jack U. Flanagan,Michael P. Hay,Debbie L. Hay +17 more
TL;DR: These are the first small-molecule positive modulators described for the CLR:RAMP complexes, and translational potential is shown as the compounds can positively modulate cAMP signaling in a vascular cell line model.
Journal ArticleDOI
Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors.
Michael L. Garelja,Michael L. Garelja,Rebekah L. Bower,Margaret A. Brimble,Shanan Chand,Paul W. R. Harris,Muhammad A. Jamaluddin,Jakeb Petersen,Andrew Siow,Christopher S. Walker,Debbie L. Hay,Debbie L. Hay +11 more
TL;DR: In this article, the authors reported the first synthesis and characterisation of mouse adrenomedullin, β-CGRP and CTR without or with mouse RAMPs, and showed that receptors containing m-CLR:m-RAMPs were generally similar to those of their human counterparts, albeit with reduced specificity.