S
Salvador Alcaire
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 3
Citations - 162
Salvador Alcaire is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Motor neuron & Central pattern generator. The author has an hindex of 3, co-authored 3 publications receiving 139 citations. Previous affiliations of Salvador Alcaire include University of Toronto.
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Journal ArticleDOI
Excitatory motor neurons are local oscillators for backward locomotion.
Shangbang Gao,Sihui Asuka Guan,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Jun Meng,Taizo Kawano,Yung-Chi Huang,Yi Li,Salvador Alcaire,Salvador Alcaire,Wesley Hung,Yangning Lu,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen,Mei Zhen +19 more
TL;DR: Motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state, and exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
Journal ArticleDOI
NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion.
Lin Xie,Shangbang Gao,Salvador Alcaire,Kyota Aoyagi,Ying Wang,Jennifer K. Griffin,Igor Stagljar,Shinya Nagamatsu,Mei Zhen +8 more
TL;DR: A conserved endoplasmic reticulum protein NLF-1 (NCA localization factor-1) is identified that regulates neuronal excitability and locomotion through the NCA channel and delivers a sodium leak channel to maintain neuronal excitable and potentiates a premotor interneuron network critical for C. elegans rhythmic locomotion.
Posted ContentDOI
Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion [preprint]
Shangbang Gao,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Yung-Chi Huang,Yi Li,Salvador Alcaire,Wesley Hung,Taizo Kawano,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen +14 more
TL;DR: It is shown that the cholinergic and excitatory class A motor neurons exhibit intrinsic and oscillatory activity, and such an activity can drive reverse locomotion without premotor interneurons.