J
Jun Meng
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 10
Citations - 167
Jun Meng is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Motor neuron & Biology. The author has an hindex of 4, co-authored 7 publications receiving 125 citations. Previous affiliations of Jun Meng include Hangzhou Normal University & University of Toronto.
Papers
More filters
Journal ArticleDOI
Excitatory motor neurons are local oscillators for backward locomotion.
Shangbang Gao,Sihui Asuka Guan,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Jun Meng,Taizo Kawano,Yung-Chi Huang,Yi Li,Salvador Alcaire,Salvador Alcaire,Wesley Hung,Yangning Lu,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen,Mei Zhen +19 more
TL;DR: Motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state, and exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
Journal ArticleDOI
Neuroendocrine modulation sustains the C. elegans forward motor state
Maria A. Lim,Jyothsna Chitturi,Jyothsna Chitturi,Valeriya Laskova,Valeriya Laskova,Jun Meng,Jun Meng,Daniel Findeis,Anne Wiekenberg,Ben Mulcahy,Linjiao Luo,Yan Li,Yan Li,Yangning Lu,Yangning Lu,Wesley Hung,Yixin Qu,Chi-Yip Ho,Douglas Holmyard,Ni Ji,Rebecca McWhirter,Aravinthan D. T. Samuel,David M. Miller,Ralf Schnabel,John A. Calarco,Mei Zhen,Mei Zhen +26 more
TL;DR: The role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans is established, and the Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID.
Journal ArticleDOI
Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation
Jun Meng,Jun Meng,Xiaoxia Ma,Huaping Tao,Xia Jin,Daniel Witvliet,James R. Mitchell,Ming Zhu,Meng-Qiu Dong,Mei Zhen,Mei Zhen,Yishi Jin,Yingchuan B. Qi +12 more
TL;DR: MYRF-1 and MYRF-2, two C. elegans homologs of Myrf family transcription factors, are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans and reveal a molecular mechanism underlying synaptic reWiring and developmental circuit plasticity.
Posted ContentDOI
Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric gait
Yangning Lu,Yangning Lu,Tosif Ahamed,Ben Mulcahy,Daniel Witvliet,Daniel Witvliet,Sihui Asuka Guan,Sihui Asuka Guan,Wesley Hung,Jun Meng,Jun Meng,Quan Wen,Aravinthan D. T. Samuel,Mei Zhen,Mei Zhen +14 more
TL;DR: In this article, the authors show that the C. elegans larva has an asymmetrically wired motor circuit, but still generates a bending pattern with dorsal-ventral symmetry, and that the juvenile motor circuit is replaced by two homologous motor circuits that separately drive dorsal and ventral bending.
Posted ContentDOI
Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion [preprint]
Shangbang Gao,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Yung-Chi Huang,Yi Li,Salvador Alcaire,Wesley Hung,Taizo Kawano,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen +14 more
TL;DR: It is shown that the cholinergic and excitatory class A motor neurons exhibit intrinsic and oscillatory activity, and such an activity can drive reverse locomotion without premotor interneurons.