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Yung-Chi Huang
Researcher at University of Massachusetts Medical School
Publications - 18
Citations - 231
Yung-Chi Huang is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 7, co-authored 10 publications receiving 160 citations. Previous affiliations of Yung-Chi Huang include Massachusetts Institute of Technology & National Taiwan University.
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Journal ArticleDOI
Excitatory motor neurons are local oscillators for backward locomotion.
Shangbang Gao,Sihui Asuka Guan,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Jun Meng,Taizo Kawano,Yung-Chi Huang,Yi Li,Salvador Alcaire,Salvador Alcaire,Wesley Hung,Yangning Lu,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen,Mei Zhen +19 more
TL;DR: Motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state, and exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
Journal ArticleDOI
Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans
Nathan Cermak,Stephanie K. Yu,Rebekah Clark,Yung-Chi Huang,Saba N Baskoylu,Steven W. Flavell +5 more
TL;DR: A new role for dopamine is identified in coupling locomotion and egg-laying together across states of the nematode C. elegans, suggesting that neuromodulators like dopamine can couple motor circuits together in a state-dependent manner.
Journal ArticleDOI
Dual Therapeutic Effects of Interferon-α Gene Therapy in a Rat Hepatocellular Carcinoma Model With Liver Cirrhosis
TL;DR: The results suggest that IFN-alpha gene therapy is a promising strategy to treat HCC patients who have concomitant liver cirrhosis.
Journal ArticleDOI
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans
Yung-Chi Huang,Jennifer K. Pirri,Diego Hernán Rayes,Shangbang Gao,Ben Mulcahy,Jeff Grant,Yasunori Saheki,Michael M. Francis,Mei Zhen,Mei Zhen,Mark J. Alkema +10 more
TL;DR: Mechanisms through which CaV2 gain-of-function mutations disrupt excitation-inhibition balance in the nervous system are revealed.
Journal ArticleDOI
Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion
TL;DR: Two multi-step motor programs executed by C. elegans in synchrony are linked, utilizing non-neuronal tissue to drive directed locomotion, and calcium waves in the intestine and proton signaling were shown to regulate the DMP.