S
Sam J. Wilson
Researcher at University of Glasgow
Publications - 57
Citations - 6372
Sam J. Wilson is an academic researcher from University of Glasgow. The author has contributed to research in topics: Viral replication & Interferon. The author has an hindex of 24, co-authored 46 publications receiving 5302 citations. Previous affiliations of Sam J. Wilson include Howard Hughes Medical Institute & Rockefeller University.
Papers
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Meta-analysis of virus-induced host gene expression reveals unique signatures of immune dysregulation induced by SARS-CoV-2
TL;DR: In this paper, a meta-analysis of these transcriptomics data available in the published literature was carried out to better understand the immune dysregulation induced by SARS-CoV-2, the causative agent of the disease.
Posted ContentDOI
Zoonotic avian influenza viruses evade human BTN3A3 restriction
Rute Maria Pinto,Siddharth Bakshi,Spyros Lytras,Mohammad Khalid Zakaria,Simon Swingler,Julie C. Worrell,Vanessa Herder,Margus Varjak,Natalia Cameron-Ruiz,Mila Collados Rodriguez,Mariana Varela,Arthur Wickenhagen,Colin Loney,Yanlong Pei,Joseph Hughes,Elise Valette,Matthew L. Turnbull,Wilhelm Furnon,Kerrie Elizabeth Hargrave,Quan Gu,Lauren Orr,Aislynn Taggart,Chris Boutell,Finn Grey,Edward C. Hutchinson,Paul Digard,Isabella Monne,Sarah K. Wootton,Megan K. L. MacLeod,Sam J. Wilson,Massimo Palmarini +30 more
TL;DR: Human BTN3A33 (butyrophilin subfamily 3 member A3) is identified as a potent inhibitor of avian but not human IAVs and sensitivity or resistance to BTn3A3 is another factor to consider in the risk assessment of the zoonotic potential of aviators.
Posted ContentDOI
TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV)
Suzannah J. Rihn,Muhamad Afiq Aziz,Douglas G. Stewart,Joseph Hughes,Matthew L. Turnbull,Mariana Varela,Elena Sugrue,Christie S. Herd,Megan L. Stanifer,Steven P. Sinkins,Massimo Palmarini,Sam J. Wilson +11 more
TL;DR: It is shown that TRIM69 is an antiviral defence that can potently and specifically block VSIV infection.
Dissertation
The reduction and induction of Kaposi's sarcoma-associated herpesvirus lytic replication.
TL;DR: The generation and characterisation of shRNA expression cassettes that can be delivered using self- inactivating lentiviral vectors are described and the role of XBP-1 as the possible molecular switch linking terminal differentiation and KSHV lytic reactivation is considered.
Journal ArticleDOI
Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion
Thomas W. M. Crozier,Edward J. D. Greenwood,James Williams,Wen-Jun Guo,Linsey Porter,Ildar Gabaev,Ana Teixeira-Silva,Guinevere L. Grice,Arthur Wickenhagen,Richard J. Stanton,Eddie Cy Wang,Sam J. Wilson,Nicholas J Matheson,James A. Nathan,Frank McCaughan,Paul J. Lehner +15 more
TL;DR: The data provide a detailed proteomic map of changes in SARS-CoV-2-infected respiratory epithelial cells in two widely used, physiologically relevant models of infection, and identify dysregulated cellular proteins and processes.