Srikeerthana Kuchi

TL;DR: In this paper, the authors show that highly upregulated interferon-stimulated genes (ISGs), which encode antiviral proteins, have distinctive nucleotide compositions, and propose that self-targeting by antiviral effectors has selected for ISG transcripts that occupy a less selftargeted sequence space.

TL;DR: The results further demonstrate the value of NAMs for grouping of UVCBs, identify informative cell lines, and provide data that could be used for justifying selection of substances for further testing that may be required for registration.

TL;DR: In this article, the authors used interferon-stimulated gene (ISG) expression screening to reveal that OAS1, through RNase L, potently inhibits SARS-CoV-2.

TL;DR: In this paper, a meta-analysis of these transcriptomics data available in the published literature was carried out to better understand the immune dysregulation induced by SARS-CoV-2, the causative agent of the disease.

TL;DR: This work determined the full sequence of the TOSV strain 1500590, a lineage A virus obtained from an infected patient and used this in combination with other sequence information to construct functional cDNA plasmids encoding the viral L, M, and S antigenomic sequences under the control of theT7 RNA promoter to recover recombinant viruses.