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Ildar Gabaev
Researcher at University of Cambridge
Publications - 15
Citations - 321
Ildar Gabaev is an academic researcher from University of Cambridge. The author has contributed to research in topics: Immune system & Viral replication. The author has an hindex of 8, co-authored 13 publications receiving 221 citations. Previous affiliations of Ildar Gabaev include Hannover Medical School.
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Journal ArticleDOI
The Human Cytomegalovirus UL51 Protein Is Essential for Viral Genome Cleavage-Packaging and Interacts with the Terminase Subunits pUL56 and pUL89
Eva Maria Borst,Jennifer Kleine-Albers,Ildar Gabaev,Marina Babić,Karen Wagner,Anne Binz,Inga Degenhardt,Markus Kalesse,Stipan Jonjić,Rudolf Bauerfeind,Martin Messerle +10 more
TL;DR: Evidence is provided that pUL51 is crucial for HCMV genome cleavage-packaging and may represent a third component of the viral terminase complex, and interference with the interactions between the terminase subunits by antiviral drugs could be a strategy to disrupt the H CMV replication cycle.
Journal ArticleDOI
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
Ildar Gabaev,Lars Steinbrück,Claudia Pokoyski,Andreas Pich,Richard J. Stanton,Reinhard Schwinzer,Thomas F. Schulz,Roland Jacobs,Martin Messerle,Penelope C. Kay-Fedorov +9 more
TL;DR: It is concluded that pUL11 has immunosuppressive properties, and that disruption of T cell function via inhibition of CD45 is a previously unknown immunomodulatory strategy of CMV.
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Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
TL;DR: It is shown how changes remodel the host cell proteome to enable viral replication in Kaposi’s sarcoma herpesvirus reactivation, an oncogenic human virus and the leading cause of mortality in HIV infection.
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Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV
Anusara Daenthanasanmak,Gustavo Salguero,Bala Sai Sundarasetty,Claudia Waskow,Kadriye Nehir Cosgun,Carlos A. Guzmán,Peggy Riese,Laura Gerasch,Andreas Schneider,Alexandra Ingendoh,Martin Messerle,Ildar Gabaev,Benno Woelk,Eliana Ruggiero,Manfred Schmidt,Christof von Kalle,Constanca Figueiredo,Britta Eiz-Vesper,Constantin von Kaisenberg,Arnold Ganser,Renata Stripecke +20 more
TL;DR: A tricistronic integrase-defective lentiviral vector capable to directly induce self-differentiation of PB and CB monocytes into dendritic cells processing pp65 is validated and supports future clinical development of SmyleDCpp65.
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A Prominent Role of the Human Cytomegalovirus UL8 Glycoprotein in Restraining Proinflammatory Cytokine Production by Myeloid Cells at Late Times during Infection.
Natàlia Pérez-Carmona,Pablo Martínez-Vicente,Domènec Farré,Ildar Gabaev,Martin Messerle,Pablo Engel,Ana Angulo +6 more
TL;DR: It is found that the UL8 protein is expressed at late times postinfection and utilized by HCMV to reduce the production of proinflammatory factors by infected myeloid cells.