G
Giulio G. Muccioli
Researcher at Université catholique de Louvain
Publications - 212
Citations - 14867
Giulio G. Muccioli is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Cannabinoid receptor & Medicine. The author has an hindex of 50, co-authored 185 publications receiving 11808 citations. Previous affiliations of Giulio G. Muccioli include École Normale Supérieure & University of Washington.
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Journal ArticleDOI
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Amandine Everard,Clara Belzer,Lucie Geurts,Janneke P. Ouwerkerk,Céline Druart,Laure B. Bindels,Yves Guiot,Muriel Derrien,Giulio G. Muccioli,Nathalie M. Delzenne,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +12 more
TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Patrice D. Cani,Sam Possemiers,T. Van de Wiele,Yves Guiot,Amandine Everard,O. Rottier,Lucie Geurts,Damien Naslain,Audrey M. Neyrinck,Didier M. Lambert,Giulio G. Muccioli,Nathalie M. Delzenne +11 more
TL;DR: It is found that a selective gut microbiota change controls and increases endogenous GLP-2 production, and consequently improves gut barrier functions by a GLP1-2-dependent mechanism, contributing to the improvement of Gut barrier functions during obesity and diabetes.
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The endocannabinoid system links gut microbiota to adipogenesis
Giulio G. Muccioli,Damien Naslain,Fredrik Bäckhed,Christopher S. Reigstad,Didier M. Lambert,Nathalie M. Delzenne,Patrice D. Cani +6 more
TL;DR: It is reported that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels, and shows that LPS acts as a master switch to control adipose tissue metabolism both in vivo and ex vivo by blocking cannabinoid‐driven adipogenesis.
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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
William R. Marrs,Jacqueline L. Blankman,Eric A. Horne,Aurore Thomazeau,Yi Hsing Lin,Jonathan Coy,Ágnes L. Bodor,Giulio G. Muccioli,Sherry Shu Jung Hu,Grace Woodruff,Susan Fung,Mathieu Lafourcade,Jessica P. Alexander,Jonathan Z. Long,Weiwei Li,Cong Xu,Thomas Möller,Ken Mackie,Olivier J. Manzoni,Benjamin F. Cravatt,Nephi Stella +20 more
TL;DR: The results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system.
Journal ArticleDOI
Obesity-Induced Neuroinflammation: Beyond the Hypothalamus.
TL;DR: The effects and mechanisms of obesity-derived neuro inflammation are discussed, with a specific emphasis on extra-hypothalamic structures, as well as the repercussions of neuroinflammation for some cerebral functions.