S
Samar I. Itani
Researcher at Boston Medical Center
Publications - 6
Citations - 2645
Samar I. Itani is an academic researcher from Boston Medical Center. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 6, co-authored 6 publications receiving 2567 citations. Previous affiliations of Samar I. Itani include Boston University.
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Journal ArticleDOI
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
TL;DR: The results indicated that the insulin resistance observed in human muscle when plasma FFA levels were elevated during euglycemic-hyperinsulinemic clamping was associated with increases in DAG mass and membrane-associated PKC-betaII and -delta and a decrease in IkappaB-alpha.
Journal ArticleDOI
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation
Eva Tomas,Tsu-Shuen Tsao,Asish K. Saha,Heather E. Murrey,Cheng Cheng Zhang,Samar I. Itani,Harvey F. Lodish,Neil B. Ruderman,Neil B. Ruderman +8 more
TL;DR: Both in vivo and in vitro, activation of AMPK was the first effect of gACRP30 and was transient, whereas alterations in malonyl CoA and ACC occurred later and were more sustained, indicating that gAC RP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation ofAMPK and perhaps other signal transduction proteins.
Journal ArticleDOI
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.
Neil B. Ruderman,Jose M. Cacicedo,Samar I. Itani,N. Yagihashi,Asish K. Saha,Ji-Ming Ye,Kai Chen,M. Zou,David Carling,Guenther Boden,R.A. Cohen,John F. Keaney,Edward W. Kraegen,Yasuo Ido +13 more
TL;DR: The reported beneficial effects of exercise and metformin on cardiovascular disease and insulin resistance in humans could be related to the fact that they activate AMPK, which inhibits all of these events and enhances insulin signalling in the endothelial cell.
Journal ArticleDOI
Protein kinase C modulates insulin action in human skeletal muscle
Ronald N. Cortright,J. L. Azevedo,Qian Zhou,Madhur K. Sinha,Walter J. Pories,Samar I. Itani,G. Lynis Dohm +6 more
TL;DR: It is demonstrated that certain PKC inhibitors augment insulin-mediated glucose uptake and suggest that PKC may modulate insulin action in human skeletal muscle.
Journal ArticleDOI
Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase.
Samar I. Itani,Asish K. Saha,Theodore G. Kurowski,Heather R. Coffin,Keith Tornheim,Neil B. Ruderman +5 more
TL;DR: It is suggested that glucose autoregulates its own transport into skeletal muscle by a mechanism involving AMPK, and changes in whole-tissue concentrations of creatine phosphate ATP, or AMP, are left open, but they leave open the possibility that alterations in a cytosolic pool of these compounds play a regulatory role.