Heather E. Murrey

TL;DR: Both in vivo and in vitro, activation of AMPK was the first effect of gACRP30 and was transient, whereas alterations in malonyl CoA and ACC occurred later and were more sustained, indicating that gAC RP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation ofAMPK and perhaps other signal transduction proteins.

TL;DR: T trimeric and HMW/hexameric Acrp30 activate different signal transduction pathways, and Acr p30 represents a novel example of the control of ligand signaling via changes in its oligomerization state.

TL;DR: The data indicate that oligomerization of Acrp30 is important for at least some of its biological activities, and changes in the relative abundance of each oligomeric isoform in plasma may regulate AcRp30 activity.

TL;DR: This review will highlight the emerging area of glyconeurobiology with an emphasis on current chemical approaches for elucidating the biological functions of glycans in the nervous system and the problems associated with oligosaccharide analysis.

TL;DR: A universal, organelle-targetable system based on HaloTag protein technology is reported for directly comparing bioorthogonal reagent reactivity, specificity, and stability using clickable HaloTag ligands in various subcellular compartments and informed the selection of optimal reagents and conditions for live-cell imaging studies.