S
Samir Z. Zard
Researcher at École Polytechnique
Publications - 584
Citations - 11608
Samir Z. Zard is an academic researcher from École Polytechnique. The author has contributed to research in topics: Xanthate & Radical. The author has an hindex of 50, co-authored 575 publications receiving 10739 citations. Previous affiliations of Samir Z. Zard include Roussel Uclaf & Centre national de la recherche scientifique.
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Transfer of chirality by the use of an all carbon tether.
TL;DR: Methylketone side chains can be used to direct the creation of one or more chiral centers, including quaternary centers, by exploiting the ability of the radical xanthate transfer process to mediate six-membered ring formation.
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Substitution of chlorocyclobutanones with xanthate salts. The remarkable effect of added base
TL;DR: The substitution reaction of chlorocyclobutanones with dithiocarbonates (xanthates) is greatly accelerated by the addition of a mild base such as DABCO or DBU as discussed by the authors.
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Efficient synthesis of the corticosteroid side-chain from 17-ketones
TL;DR: Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphonate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.
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A convergent approach to polycyclic aromatic hydrocarbons.
TL;DR: A new concise route to Polycyclic Aromatic Hydrocarbons (PAHs) through radical addition and cyclisation of xanthates is described.
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The xanthate route to pyridines
TL;DR: In this paper, a variety of pyridines involving radical additions of xanthates are described, with emphasis on reactions leading to tetrahydropyridine synthesis and the formation of 1,5-diketones or 1.5-ketoaldehydes.