S
Samir Z. Zard
Researcher at École Polytechnique
Publications - 584
Citations - 11608
Samir Z. Zard is an academic researcher from École Polytechnique. The author has contributed to research in topics: Xanthate & Radical. The author has an hindex of 50, co-authored 575 publications receiving 10739 citations. Previous affiliations of Samir Z. Zard include Roussel Uclaf & Centre national de la recherche scientifique.
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Journal ArticleDOI
The Xanthate Route to Indolines, Indoles, and their Aza Congeners
TL;DR: Convergent routes to a variety of indolines, indoles, oxindoles, and their aza analogues involving radical additions of xanthates involving radical addition to the pyrrole subunit of the indole nucleus are described.
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An efficient and short degradation of the cholic acid side chain: a new method for the preparation and dehydrogenation of 4,5-dihydro-oxazoles
TL;DR: In this article, boric acid mediated condensation with 2-amino-2-methylpropan-1-ol was used to give the corresponding 4,5-dihydro-oxazoles.
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Tri- and tetrasubstituted functionalized vinyl sulfides by radical allylation.
TL;DR: Vinyl sulfides were used as more robust enol ether surrogates in highly stereoselective reactions with N-acylium cations leading to nitrogen-containing polycyclic structures.
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A convergent radical-based route to biaryls.
TL;DR: A route to biaryl-3-carboxylate esters involving a radical 1,2-aryl migration has been developed and this strategy hinges on the radical addition of xanthate 2 to olefin 1 causing a 1, 2-aryl shift leading to alpha,beta-unsaturated ester 5, which is then converted into biaryl 10 by treatment with DBU under microwave heating.
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On the Trail of Xanthates: Some New Chemistry from an Old Functional Group
TL;DR: The use of free radical reactions in organic synthesis has witnessed an extraordinary development in recent years as discussed by the authors, and the number of synthetically useful radical-generating systems is still limited, and most applications have relied on tin hydride chemistry.