S
Samuel E. Driver
Researcher at Carnegie Institution for Science
Publications - 8
Citations - 17787
Samuel E. Driver is an academic researcher from Carnegie Institution for Science. The author has contributed to research in topics: DNA-directed RNA interference & RNA interference. The author has an hindex of 5, co-authored 8 publications receiving 16965 citations. Previous affiliations of Samuel E. Driver include Boston Children's Hospital & University of Massachusetts Amherst.
Papers
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Journal ArticleDOI
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Andrew Fire,SiQun Xu,Mary K. Montgomery,Steven A. Kostas,Steven A. Kostas,Samuel E. Driver,Craig C. Mello +6 more
TL;DR: To their surprise, it was found that double-stranded RNA was substantially more effective at producing interference than was either strand individually, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process.
Patent
Genetic Inhibition by Double-Stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.
Journal ArticleDOI
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor.
Lois E.H. Smith,Wei Shen,Carole A. Perruzzi,Shay Soker,Fumi Kinose,Xianghong Xu,Gregory S. Robinson,Samuel E. Driver,Joyce Bischoff,Bei Zhang,James M. Schaeffer,Donald R. Senger +11 more
TL;DR: Findings establish an essential role for IGF-1 in angiogenesis and demonstrate a new target for control of retinopathy, and explain why diabetic Retinopathy initially increases with the onset of insulin treatment.
Journal ArticleDOI
Oligonucleotide-based inhibition of embryonic gene expression.
Samuel E. Driver,Gregory S. Robinson,Jean Flanagan,Wei Shen,Lois E.H. Smith,David W. Thomas,Peter C. Roberts +6 more
TL;DR: This is the first report of AS-ODN inhibition of gene expression in utero and provides a new strategy for target validation in functional genomics.
Patent
Genetic inhibition of double-stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.