H
Hiroaki Tabara
Researcher at University of Tokushima
Publications - 10
Citations - 5801
Hiroaki Tabara is an academic researcher from University of Tokushima. The author has contributed to research in topics: RNA interference & RNA silencing. The author has an hindex of 9, co-authored 9 publications receiving 5683 citations. Previous affiliations of Hiroaki Tabara include Carnegie Institution for Science & University of Massachusetts Medical School.
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Genetic Inhibition by Double-Stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.
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The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
Hiroaki Tabara,Madathia Sarkissian,William G. Kelly,Jamie Fleenor,Alla Grishok,Lisa Timmons,Andrew Fire,Craig C. Mello +7 more
TL;DR: It is shown that rde-1 is a member of the piwi/sting/argonaute/zwille/eIF2C gene family conserved from plants to vertebrates and the possibility that one natural function of RNAi is transposon silencing is discussed.
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RNAi in C. elegans: Soaking in the Genome Sequence
TL;DR: The completion of the Caenorhabditis elegans genome sequence represents a major milestone in a journey initiated by Sydney Brenner some 30 years ago to discover how genetic information specifies the development, anatomy, and behavior of a simple animal.
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The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans
TL;DR: This work shows that the C. elegans RNAi pathway gene, rde-4, encodes a dsRNA binding protein that interacts during RNAi with RNA identical to the trigger dsRNAs, and suggests a model in which RDE-4 and Rde-1 function together to detect and retain foreign ds RNA and to present this ds RNAs to DCR-1 for processing.
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Genetic Requirements for Inheritance of RNAi in C. elegans
TL;DR: Findings provide evidence for germ line transmission of an extragenic sequence-specific silencing factor and implicate rde-1 and r de-4 in the formation of the inherited agent.