L
Lisa Timmons
Researcher at University of Kansas
Publications - 31
Citations - 9191
Lisa Timmons is an academic researcher from University of Kansas. The author has contributed to research in topics: RNA silencing & RNA interference. The author has an hindex of 19, co-authored 29 publications receiving 8853 citations. Previous affiliations of Lisa Timmons include Johns Hopkins University & American Red Cross.
Papers
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Journal ArticleDOI
Specific interference by ingested dsRNA
Lisa Timmons,Andrew Fire +1 more
TL;DR: This work shows that C. elegans can respond in a gene-specific manner to dsRNA encountered in the environment, and finds that Escherichia coli bacteria expressing dsRNAs can confer specific interference effects on the nematode larvae that feed on them.
Journal ArticleDOI
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
TL;DR: An efficient induction of RNAi using bacteria to deliver double-stranded RNA is reported, found to be most effective in inducing RNAi for non-neuronal tissue of late larval and adult hermaphrodites, with decreased effectiveness in the nervous system, in early larval stages, and in males.
Patent
Genetic Inhibition by Double-Stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.
Journal ArticleDOI
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
Hiroaki Tabara,Madathia Sarkissian,William G. Kelly,Jamie Fleenor,Alla Grishok,Lisa Timmons,Andrew Fire,Craig C. Mello +7 more
TL;DR: It is shown that rde-1 is a member of the piwi/sting/argonaute/zwille/eIF2C gene family conserved from plants to vertebrates and the possibility that one natural function of RNAi is transposon silencing is discussed.
Journal ArticleDOI
On the role of RNA amplification in dsRNA-triggered gene silencing.
Titia Sijen,Jamie Fleenor,Femke Simmer,Karen L. Thijssen,Susan Parrish,Susan Parrish,Lisa Timmons,Ronald H.A. Plasterk,Andrew Fire +8 more
TL;DR: Analysis of small interfering RNAs produced during RNAi in C. elegans revealed a substantial fraction that cannot derive directly from input dsRNA, and appeared to derive from the action of a cellular RNA-directed RNA polymerase (RdRP) on mRNAs that are being targeted by the RNAi mechanism.