Sandra Jacinto

TL;DR: It is found that Fex reduces diet-induced weight gain, body-wide inflammation and hepatic glucose production, while enhancing thermogenesis and browning of white adipose tissue (WAT), suggesting tissue-restricted FXR activation as a new approach in the treatment of obesity and metabolic syndrome.

TL;DR: These studies characterize a previously unrecognized, ERR-dependent metabolic gate prior to establishment of induced pluripotency, and identify a rare pool of Sca1(-)/CD34(-) sortable cells that is highly enriched in bona fide reprogramming progenitors.

TL;DR: Findings reveal a role for ERRγ as a critical thermoneutral maintenance factor required to prime BAT for thermogenesis and indicate marked downregulation of BAT-selective genes that leads to a pronounced whitening of BAT.

TL;DR: Two types of epigenetic mechanisms are identified that distinguish the pre-set cell fate and later stages of adipose differentiation in induced pluripotent stem cells and adipose derived stem cells.

TL;DR: These metabolic regulators: FXR and TGR5 are essential modulators in the metabolic system, which affect the human machinery and will be the focus of this review.