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Yasuyuki S. Kida
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 50
Citations - 3388
Yasuyuki S. Kida is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 18, co-authored 44 publications receiving 3067 citations. Previous affiliations of Yasuyuki S. Kida include Life Sciences Institute & Tohoku University.
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Journal ArticleDOI
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Ryan Lister,Mattia Pelizzola,Yasuyuki S. Kida,R. David Hawkins,Joseph R. Nery,Gary C. Hon,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ronan C. O'Malley,Rosa Castanon,Sarit Klugman,Michael Downes,Ruth T. Yu,Ron Stewart,Ron Stewart,Bing Ren,Bing Ren,James A. Thomson,Ronald M. Evans,Joseph R. Ecker +19 more
TL;DR: The first whole-genome profiles of DNA methylation at single-base resolution in five human iPSC lines, along with methylomes of ES cells, somatic cells, and differentiated iPSCs and ES cells are reported.
Journal ArticleDOI
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.
Athanasia D. Panopoulos,Oscar Yanes,Sergio Ruiz,Yasuyuki S. Kida,Dinh Diep,Ralf Tautenhahn,Aída Herrerías,Erika M. Batchelder,Nongluk Plongthongkum,Margaret Lutz,W. Travis Berggren,Kun Zhang,Ronald M. Evans,Gary Siuzdak,Juan Carlos Izpisua Belmonte +14 more
TL;DR: These findings are the first to globally analyze the metabolome of iPSCs, and provide mechanistic insight into a new layer of regulation involved in inducing pluripotency, and in evaluating iPSC and ESC equivalence.
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Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells
Shigeki Sugii,Yasuyuki S. Kida,Teruhisa Kawamura,Jotaro Suzuki,Rita Vassena,Yun-Qiang Yin,Margaret Lutz,W. Travis Berggren,Juan Carlos Izpisúa Belmonte,Ronald M. Evans +9 more
TL;DR: It is reported that adult human and mouse adipose-derived stem cells can be reprogrammed to induced pluripotent stem (iPS) cells with substantially higher efficiencies than those reported for human andmouse fibroblasts.
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ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells
Eiji Yoshihara,Zong Wei,Chun Shi Lin,Sungsoon Fang,Sungsoon Fang,Maryam Ahmadian,Yasuyuki S. Kida,Yasuyuki S. Kida,Tiffany W. Tseng,Yang Dai,Ruth T. Yu,Christopher Liddle,Annette R. Atkins,Michael Downes,Ronald M. Evans +14 more
TL;DR: A key role is identified for ERRγ in β cell metabolic maturation, and this work offers a reproducible, quantifiable, and scalable approach for in vitro generation of functional human β cell therapeutics.
Journal ArticleDOI
ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency
Yasuyuki S. Kida,Yasuyuki S. Kida,Teruhisa Kawamura,Teruhisa Kawamura,Zong Wei,Takahiro Sogo,Sandra Jacinto,Asako Shigeno,Asako Shigeno,Hiroko Kushige,Eiji Yoshihara,Christopher Liddle,Joseph R. Ecker,Ruth T. Yu,Annette R. Atkins,Michael Downes,Ronald M. Evans +16 more
TL;DR: These studies characterize a previously unrecognized, ERR-dependent metabolic gate prior to establishment of induced pluripotency, and identify a rare pool of Sca1(-)/CD34(-) sortable cells that is highly enriched in bona fide reprogramming progenitors.