D
Daniel Keszthelyi
Researcher at Maastricht University
Publications - 146
Citations - 3806
Daniel Keszthelyi is an academic researcher from Maastricht University. The author has contributed to research in topics: Irritable bowel syndrome & Medicine. The author has an hindex of 30, co-authored 115 publications receiving 2380 citations. Previous affiliations of Daniel Keszthelyi include King's College London & Maastricht University Medical Centre.
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Journal ArticleDOI
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Arnau Vich Vila,Floris Imhann,Valerie Collij,Soesma A Jankipersadsing,Thomas Gurry,Thomas Gurry,Zlatan Mujagic,Alexander Kurilshikov,Marc Jan Bonder,Xiaofang Jiang,Xiaofang Jiang,Ettje F. Tigchelaar,Jackie A M Dekens,Vera Peters,Michiel Voskuil,Marijn C. Visschedijk,Hendrik M. van Dullemen,Daniel Keszthelyi,Morris A. Swertz,Lude Franke,Rudi Alberts,Eleonora A. M. Festen,Gerard Dijkstra,Ad A.M. Masclee,Marten H. Hofker,Ramnik J. Xavier,Ramnik J. Xavier,Eric J. Alm,Eric J. Alm,Jingyuan Fu,Cisca Wijmenga,Daisy Jonkers,Alexandra Zhernakova,Rinse K. Weersma +33 more
TL;DR: A case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population was able to use gut microbiota composition differences to distinguish patients with I BD from those with IBS.
Journal ArticleDOI
Large-scale association analyses identify host factors influencing human gut microbiome composition
Alexander Kurilshikov,Carolina Medina-Gomez,Rodrigo Bacigalupe,Djawad Radjabzadeh,Jun Wang,Jun Wang,Ayse Demirkan,Ayse Demirkan,Caroline I. Le Roy,Juan Antonio Raygoza Garay,Casey T. Finnicum,Xingrong Liu,Daria V. Zhernakova,Marc Jan Bonder,Tue H. Hansen,Fabian Frost,Malte C. Rühlemann,Williams Turpin,Jee-Young Moon,Han-Na Kim,Kreete Lüll,Elad Barkan,Shiraz A. Shah,Myriam Fornage,Joanna Szopinska-Tokov,Zachary D. Wallen,Dmitrii Borisevich,Lars Agréus,Anna Andreasson,Corinna Bang,Larbi Bedrani,Jordana T. Bell,Hans Bisgaard,Michael Boehnke,Dorret I. Boomsma,Robert D. Burk,Annique Claringbould,Kenneth Croitoru,Gareth E. Davies,Gareth E. Davies,Cornelia M. van Duijn,Cornelia M. van Duijn,Liesbeth Duijts,Gwen Falony,Jingyuan Fu,Adriaan van der Graaf,Torben Hansen,Georg Homuth,David A. Hughes,Richard G. IJzerman,Matthew A. Jackson,Matthew A. Jackson,Vincent W. V. Jaddoe,Marie Joossens,Torben Jørgensen,Daniel Keszthelyi,Rob Knight,Markku Laakso,Matthias Laudes,Lenore J. Launer,Wolfgang Lieb,Aldons J. Lusis,Ad A.M. Masclee,Henriette A. Moll,Zlatan Mujagic,Qi Qibin,Daphna Rothschild,Hocheol Shin,Søren J. Sørensen,Claire J. Steves,Jonathan Thorsen,Nicholas J. Timpson,Raul Y. Tito,Sara Vieira-Silva,Uwe Völker,Henry Völzke,Urmo Võsa,Kaitlin H Wade,Susanna Walter,Kyoko Watanabe,Stefan Weiss,Frank Ulrich Weiss,Omer Weissbrod,Harm-Jan Westra,Gonneke Willemsen,Haydeh Payami,Daisy Jonkers,Alejandro Arias Vasquez,Eco J. C. de Geus,Katie A. Meyer,Jakob Stokholm,Eran Segal,Elin Org,Cisca Wijmenga,Hyung Lae Kim,Robert C. Kaplan,Tim D. Spector,André G. Uitterlinden,Fernando Rivadeneira,Andre Franke,Markus M. Lerch,Lude Franke,Serena Sanna,Serena Sanna,Mauro D'Amato,Oluf Pedersen,Andrew D. Paterson,Robert Kraaij,Jeroen Raes,Alexandra Zhernakova +109 more
TL;DR: In this article, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts) and found high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples.
Journal ArticleDOI
Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function
TL;DR: This review analyses the current knowledge of the interrelationship between tryptophan metabolic pathways and summarizes the existing scientific evidence regarding the role of tryptophile metabolites in intestinal function and in the pathogenesis of gastrointestinal diseases.
Posted ContentDOI
Large-scale association analyses identify host factors influencing human gut microbiome composition
Alexander Kurilshikov,Carolina Medina-Gomez,Rodrigo Bacigalupe,Djawad Radjabzadeh,Jun Wang,Ayse Demirkan,Ayse Demirkan,Caroline I. Le Roy,Juan Antonio Raygoza Garay,Juan Antonio Raygoza Garay,Casey T. Finnicum,Xingrong Liu,Daria V. Zhernakova,Daria V. Zhernakova,Marc Jan Bonder,Tue H. Hansen,Fabian Frost,Malte C. Rühlemann,Williams Turpin,Williams Turpin,Jee-Young Moon,Han-Na Kim,Kreete Lüll,Elad Barkan,Shiraz A. Shah,Myriam Fornage,Joanna Szopinska-Tokov,Zachary D. Wallen,Dmitrii Borisevich,Lars Agréus,Anna Andreasson,Corinna Bang,Larbi Bedrani,Jordana T. Bell,Hans Bisgaard,Michael Boehnke,Dorret I. Boomsma,Robert D. Burk,Annique Claringbould,Kenneth Croitoru,Kenneth Croitoru,Gareth E. Davies,Cornelia M. van Duijn,Cornelia M. van Duijn,Liesbeth Duijts,Gwen Falony,Jingyuan Fu,Adriaan van der Graaf,Torben Hansen,Georg Homuth,David A. Hughes,Richard G. IJzerman,Matthew A. Jackson,Matthew A. Jackson,Vincent W. V. Jaddoe,Marie Joossens,Torben Jørgensen,Daniel Keszthelyi,Rob Knight,Markku Laakso,Matthias Laudes,Lenore J. Launer,Wolfgang Lieb,Aldons J. Lusis,Ad A.M. Masclee,Henriette A. Moll,Zlatan Mujagic,Qi Qibin,Daphna Rothschild,Hocheol Shin,Søren J. Sørensen,Claire J. Steves,Jonathan Thorsen,Nicholas J. Timpson,Raul Y. Tito,Sara Vieira-Silva,Uwe Völker,Henry Völzke,Urmo Võsa,Kaitlin H Wade,Susanna Walter,Kyoko Watanabe,Stefan Weiss,Frank Ulrich Weiss,Omer Weissbrod,Harm-Jan Westra,Gonneke Willemsen,Haydeh Payami,Daisy Jonkers,Alejandro Arias Vasquez,Eco J. C. de Geus,Katie A. Meyer,Jakob Stokholm,Eran Segal,Elin Org,Cisca Wijmenga,Hyung Lae Kim,Robert C. Kaplan,Tim D. Spector,André G. Uitterlinden,Fernando Rivadeneira,Andre Franke,Markus M. Lerch,Lude Franke,Serena Sanna,Serena Sanna,Mauro D'Amato,Oluf Pedersen,Andrew D. Paterson,Robert Kraaij,Jeroen Raes,Alexandra Zhernakova +111 more
TL;DR: A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome has causal effects in ulcerative colitis and rheumatoid arthritis.
Journal ArticleDOI
Leaky gut and diabetes mellitus: what is the link?
TL;DR: This review analyses recent advances in the mechanistic understanding of the role of the intestinal epithelial barrier function in the development of type 1 and type 2 diabetes to assume that reinforcing the intestinal barrier can offer and open new therapeutic horizons in the treatment of types 1 and 2 diabetes.