S
Sandra Winter
Researcher at Humboldt University of Berlin
Publications - 8
Citations - 696
Sandra Winter is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: G protein & Synaptic vesicle. The author has an hindex of 8, co-authored 8 publications receiving 653 citations. Previous affiliations of Sandra Winter include Charité.
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Journal ArticleDOI
Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release
Diego J. Walther,Jens-Uwe Peter,Sandra Winter,Markus Höltje,Nils Paulmann,Maik Grohmann,Jakob Vowinckel,Victor Alamo-Bethencourt,Claudia S. Wilhelm,Gudrun Ahnert-Hilger,Michael Bader +10 more
TL;DR: It is shown that mice selectively deficient in peripheral TPH and serotonin exhibit impaired hemostasis, resulting in a reduced risk of thrombosis and thromboembolism, although the ultrastructure of the platelets is not affected.
Journal ArticleDOI
The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake.
Irene Brunk,Christian Blex,Sivaramakrishna Rachakonda,Markus Höltje,Sandra Winter,Ingrid Pahner,Diego J. Walther,Gudrun Ahnert-Hilger +7 more
TL;DR: Vesicular content is involved in the activation of vesicle associated G-proteins via a structure sensing the luminal monoamine content through the first luminal loop of VMATs, which may represent a G-protein-coupled receptor that adapts vesicular filling.
Journal ArticleDOI
The Vesicular Monoamine Content Regulates VMAT2 Activity through Gαq in Mouse Platelets EVIDENCE FOR AUTOREGULATION OF VESICULAR TRANSMITTER UPTAKE
Markus Höltje,Sandra Winter,Diego J. Walther,Ingrid Pahner,Ingrid Pahner,Heide Hörtnagl,Ole Petter Ottersen,Michael Bader,Gudrun Ahnert-Hilger +8 more
TL;DR: It is concluded that in platelets the vesicle itself regulates transmitter transporter activity via its content and vesicles-associated Gαq, mediating the down-regulation of VMAT2 activity.
Journal ArticleDOI
G alpha(o2) regulates vesicular glutamate transporter activity by changing its chloride dependence
Sandra Winter,Irene Brunk,Diego J. Walther,Markus Höltje,Meisheng Jiang,Jens-Uwe Peter,Shigeo Takamori,Reinhard Jahn,Lutz Birnbaumer,Gudrun Ahnert-Hilger +9 more
TL;DR: It is shown that VGLUTs are exclusively regulated by G αo2, and Gαo2 acts on a putative regulatory chloride binding domain that appears to modulate transport activity of vesicular glutamate transporters.
Book ChapterDOI
Regulation of vesicular neurotreansmitter transporters
TL;DR: It appears that the vesicular content activates the G protein, suggesting a signal transduction form the luminal site which might be mediated by a vESicular G-protein coupled receptor or, as an alternative, possibly by the transporter itself.