S
Sandra Yassine
Researcher at University of Grenoble
Publications - 7
Citations - 758
Sandra Yassine is an academic researcher from University of Grenoble. The author has contributed to research in topics: Sperm & Globozoospermia. The author has an hindex of 7, co-authored 7 publications receiving 592 citations. Previous affiliations of Sandra Yassine include Centre national de la recherche scientifique & Joseph Fourier University.
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Journal ArticleDOI
Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.
Mariem Ben Khelifa,Mariem Ben Khelifa,Mariem Ben Khelifa,Charles Coutton,Charles Coutton,Raoudha Zouari,Thomas Karaouzène,Thomas Karaouzène,John Rendu,John Rendu,Marie Bidart,Marie Bidart,Sandra Yassine,Sandra Yassine,Virginie Pierre,Virginie Pierre,Julie Delaroche,Julie Delaroche,Sylviane Hennebicq,Sylviane Hennebicq,Didier Grunwald,Didier Grunwald,Denise Escalier,Karine Pernet-Gallay,Karine Pernet-Gallay,Pierre-Simon Jouk,Nicolas Thierry-Mieg,Aminata Touré,Aminata Touré,Aminata Touré,Christophe Arnoult,Christophe Arnoult,Pierre F. Ray,Pierre F. Ray +33 more
TL;DR: Infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum, and genetic etiology is likely in most cases.
Journal ArticleDOI
Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus
Virginie Pierre,Virginie Pierre,Guillaume Martinez,Guillaume Martinez,Charles Coutton,Charles Coutton,Julie Delaroche,Julie Delaroche,Sandra Yassine,Sandra Yassine,Caroline Novella,Caroline Novella,Karin Pernet-Gallay,Karin Pernet-Gallay,Sylviane Hennebicq,Sylviane Hennebicq,Pierre F. Ray,Pierre F. Ray,Christophe Arnoult,Christophe Arnoult +19 more
TL;DR: The absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina (NDL) and the junction between the acroplaxome and the nuclear envelope leading to the disruption of vesicular trafficking, failure of sperm nuclear shaping and eventually to the elimination of the unbound acrosomal vesicle.
Journal ArticleDOI
Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP
Jessica Escoffier,Hoi Chang Lee,Sandra Yassine,Raoudha Zouari,Guillaume Martinez,Thomas Karaouzène,Charles Coutton,Zine Eddine Kherraf,Lazhar Halouani,Chema Triki,Serge Nef,Nicolas Thierry-Mieg,Sergey N. Savinov,Rafael A. Fissore,Pierre F. Ray,Christophe Arnoult +15 more
TL;DR: It is demonstrated in humans, the absence of PLCZ1 alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP, and the first mutation located in the C2 domain of P LCZ1, a domain involved in targeting proteins to cell membranes is shown, opening the door to structure-function studies.
Journal ArticleDOI
Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.
Jessica Escoffier,Sandra Yassine,Sandra Yassine,Hoi Chang Lee,Guillaume Martinez,Guillaume Martinez,Julie Delaroche,Charles Coutton,Thomas Karaouzène,Thomas Karaouzène,Raoudha Zouari,Catherine Metzler-Guillemain,Karin Pernet-Gallay,Karin Pernet-Gallay,Sylviane Hennebicq,Pierre F. Ray,Rafael A. Fissore,Christophe Arnoult +17 more
TL;DR: It is shown that chromatin compaction during spermiogenesis in Dpy19l2 KO mouse is defective and leads to sperm DNA damage, which explains the poor fertilization potential of DPY19L2-globozoospermic sperm and the compromised developmental potential of embryos obtained using sperm from patients with a deletion of the DPY 19L2 gene.
Journal ArticleDOI
Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development
Sandra Yassine,Jessica Escoffier,Jessica Escoffier,Guillaume Martinez,Guillaume Martinez,Charles Coutton,Thomas Karaouzène,Thomas Karaouzène,Raoudha Zouari,Jean-Luc Ravanat,Catherine Metzler-Guillemain,Hoi Chang Lee,Rafael A. Fissore,Sylviane Hennebicq,Pierre F. Ray,Christophe Arnoult +15 more
TL;DR: It is shown that chromatin compaction during spermiogenesis in Dpy19l2 KO mouse is defective and leads to sperm DNA damage, which may largely explain the poor embryonic development of most mouse and human embryos obtained with globozoospermic sperm.