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Zine Eddine Kherraf
Researcher at University of Grenoble
Publications - 5
Citations - 223
Zine Eddine Kherraf is an academic researcher from University of Grenoble. The author has contributed to research in topics: Intraflagellar transport & Flagellum. The author has an hindex of 3, co-authored 5 publications receiving 149 citations. Previous affiliations of Zine Eddine Kherraf include Centre Hospitalier Universitaire de Grenoble & French Institute of Health and Medical Research.
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Journal ArticleDOI
Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP
Jessica Escoffier,Hoi Chang Lee,Sandra Yassine,Raoudha Zouari,Guillaume Martinez,Thomas Karaouzène,Charles Coutton,Zine Eddine Kherraf,Lazhar Halouani,Chema Triki,Serge Nef,Nicolas Thierry-Mieg,Sergey N. Savinov,Rafael A. Fissore,Pierre F. Ray,Christophe Arnoult +15 more
TL;DR: It is demonstrated in humans, the absence of PLCZ1 alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP, and the first mutation located in the C2 domain of P LCZ1, a domain involved in targeting proteins to cell membranes is shown, opening the door to structure-function studies.
Journal ArticleDOI
Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice.
Wangjie Liu,Xiaojin He,Shenmin Yang,Raoudha Zouari,Jiaxiong Wang,Huan Wu,Zine Eddine Kherraf,Chunyu Liu,Chunyu Liu,Charles Coutton,Rui Zhao,Dongdong Tang,Shuyan Tang,Mingrong Lv,Youyan Fang,Weiyu Li,Weiyu Li,Hong Li,Jian-Yuan Zhao,Xue Wang,Shimin Zhao,Jingjing Zhang,Christophe Arnoult,Li Jin,Zhiguo Zhang,Pierre F. Ray,Pierre F. Ray,Yunxia Cao,Feng Zhang +28 more
TL;DR: Wang et al. as discussed by the authors used whole-exome sequencing in a cohort of 65 Han Chinese men with MMAF and revealed sperm structural defects of the flagella and the connecting piece.
Journal ArticleDOI
The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility
Wei Qu,Shuo Yuan,Shuo Yuan,Chao Quan,Qian Huang,Qian Huang,Qi Zhou,Qi Zhou,Yitian Yap,Lin Shi,Lin Shi,David Zhang,Tamia Guest,Wei Li,Siu-Pok Yee,Ling Zhang,Caroline Cazin,Rex A. Hess,Pierre F. Ray,Pierre F. Ray,Zine Eddine Kherraf,Zine Eddine Kherraf,Zhibing Zhang +22 more
TL;DR: It is shown that IFT81 plays an essential role during spermatogenesis by modulating the assembly and elongation of the sperm flagella and that its absence is associated with abnormal flagellum formation leading to male infertility.
Posted ContentDOI
CFAP61 is required for sperm flagellum formation and male fertility in human and mouse
Siyu Liu,Jintao Zhang,Zine Eddine Kherraf,Shuya Sun,Xin Zhang,Caroline Cazin,Charles Coutton,Raoudha Zouari,Shuqin Zhao,Fan Hu,Selima Fourati Ben Mustapha,Christophe Arnoult,Pierre F. Ray,Mingxi Liu +13 more
TL;DR: This article found that CFAP61 is a conserved component of the Calmodulin and radial Spoke associated Complex (CSC) of cilia and showed that the axoneme in Cfap61−/− cells becomes unstable and scatters and the distribution of intraflagellar transport proteins is disrupted.
Caractérisation moléculaire et physiopathologique d'une nouvelle cause génétique de l'azoospermie non obstructive
TL;DR: La proteine codee par ce gene est exprimee dans l’acrosome a partir du stade de spermatide ronde d’azoospermie peuvent constituer un continuum pathologique du a une meme pathogenie.