R
Rafael A. Fissore
Researcher at University of Massachusetts Amherst
Publications - 163
Citations - 9085
Rafael A. Fissore is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Oocyte activation & Sperm. The author has an hindex of 56, co-authored 161 publications receiving 8490 citations. Previous affiliations of Rafael A. Fissore include Tufts University & Harvard University.
Papers
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Journal ArticleDOI
Egg-to-embryo transition is driven by differential responses to Ca(2+) oscillation number.
Tom Ducibella,Daniel Huneau,Elizabeth Lloyd Angelichio,Zhe Xu,Richard M. Schultz,Gregory S. Kopf,Rafael A. Fissore,Stephane Madoux,Jean-Pierre Ozil +8 more
TL;DR: There is strong evidence that a single Ca(2+) transient-driven signaling system can initiate and drive a cell into a new developmental pathway, as well as can account for the temporal sequence of cellular changes associated with early development.
Journal ArticleDOI
Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development
Sook-Young Yoon,Teru Jellerette,Ana M. Salicioni,Hoi Chang Lee,Myung-sik Yoo,Kevin Coward,John Parrington,Daniel Grow,Jose B. Cibelli,Pablo E. Visconti,Jesse Mager,Rafael A. Fissore +11 more
TL;DR: The results indicate that the inability of human sperm to initiate [Ca(2+)](i) oscillations leads to failure of egg activation and sterility and that abnormal PLCZ1 expression underlies this functional defect.
Journal ArticleDOI
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
Elke Heytens,John Parrington,Kevin Coward,Kevin Coward,C Young,S Lambrecht,Sook-Young Yoon,Rafael A. Fissore,R. Hamer,Charlotte M. Deane,Margarida Ruas,P Grasa,R. Soleimani,Claude Cuvelier,Jan Gerris,Marc Dhont,Dieter Deforce,Luc Leybaert,P. De Sutter +18 more
TL;DR: The findings illustrate the importance of PLCzeta during fertilization and suggest that mutant forms of P LCzeta may underlie certain types of human male infertility.
Journal ArticleDOI
The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development.
Tom Ducibella,Rafael A. Fissore +1 more
TL;DR: In this article, a review covers recent studies that have analyzed how these Ca(2+) signals are interpreted by specific proteins, and how these proteins regulate various EEA responsible for the onset of development.
Book ChapterDOI
Fertilization in Mammals
TL;DR: The cellular events of sperm–egg interaction result in gamete fusion and the initiation of the program of development and are further described in this chapter.