Sandy Klemm

TL;DR: In this paper, the authors utilized two gene expression technologies to profile 48 genes in single cells at various stages during the reprogramming process and found that expression of Esrrb, Utf1, Lin28, and Dppa2 is a better predictor for cells to progress into iPSCs than expression of the previously suggested reprogrammer markers Fbxo15, Fgf4, and Oct4.

TL;DR: Theoretical and experimental analyses show that microRNAs can reduce fluctuations in gene expression and suggest that miRNAs confer precision to protein expression and thus offer plausible explanations for the commonly observed combinatorial targeting of endogenous genes by multiple miRN as well as the preferential targeting of lowly expressed genes.

TL;DR: A database of over 4.3 million primer pairs targeting the human and mouse genomes that is readily usable for rapid and flexible generation of probes is provided.

TL;DR: This work demonstrates efficient and unbiased RNA extraction from transcriptionally sorted cells and reports a high-fidelity transcriptome measurement of mouse induced pluripotent stem cells (iPSCs) isolated from a heterogeneous reprogramming culture.

TL;DR: In this article , the effect of repeated malaria exposure on natural killer (NK) cells was investigated in a cohort of 264 Ugandan children, and it was found that higher frequencies of CD56neg NK cells were associated with protection against symptomatic malaria and high parasite densities.