S
Sankar Mohan
Researcher at Genentech
Publications - 112
Citations - 4805
Sankar Mohan is an academic researcher from Genentech. The author has contributed to research in topics: Raman spectroscopy & HOMO/LUMO. The author has an hindex of 35, co-authored 111 publications receiving 4384 citations. Previous affiliations of Sankar Mohan include Albert Einstein College of Medicine & Medical University of South Carolina.
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Journal ArticleDOI
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
William Lee,Zhaoshi Jiang,Jinfeng Liu,Peter M. Haverty,Yinghui Guan,Jeremy Stinson,Peng Yue,Yan Zhang,Krishna P. Pant,Deepali Bhatt,Connie Ha,Stephanie Johnson,Michael I. Kennemer,Sankar Mohan,Igor Nazarenko,Colin K. Watanabe,Andrew B. Sparks,David S. Shames,Robert Gentleman,Frederic J. de Sauvage,Howard M. Stern,Ajay Pandita,Dennis G. Ballinger,Radoje Drmanac,Zora Modrusan,Somasekar Seshagiri,Zemin Zhang +26 more
TL;DR: A comprehensive view of somatic alterations in a single lung tumour is presented, and the first evidence, to the authors' knowledge, of distinct selective pressures present within the tumour environment is provided.
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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.
Albert Lai,Samir Kharbanda,Whitney B. Pope,Anh Tran,Orestes E. Solis,Franklin Peale,William F. Forrest,Kanan Pujara,Jose Carrillo,Ajay Pandita,Benjamin M. Ellingson,Chauncey W. Bowers,Robert Soriano,Nils Ole Schmidt,Sankar Mohan,William H. Yong,Somasekar Seshagiri,Zora Modrusan,Zhaoshi Jiang,Kenneth Aldape,Paul S. Mischel,Linda M. Liau,Cameron Escovedo,Weidong Chen,Phioanh L. Nghiemphu,C. David James,Michael D. Prados,Manfred Westphal,Katrin Lamszus,Timothy F. Cloughesy,Heidi S. Phillips,Heidi S. Phillips +31 more
TL;DR: Although histologically similar, GBMs arising with and without IDH1(R132MUT) appear to represent distinct disease entities that arise from separate cell types of origin as the result of largely nonoverlapping sets of molecular events.
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Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.
Eva Lin,Li Li,Yinghui Guan,Robert Soriano,Celina Sanchez Rivers,Sankar Mohan,Ajay Pandita,Jerry Tang,Zora Modrusan +8 more
TL;DR: Findings show the recurrence of EML4-ALK fusion in multiple solid tumors and further substantiate its role in tumorigenesis, as well as elucidate the functional significance of the gene.
Journal ArticleDOI
Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.
Julie E. Ledgerwood,Emily E. Coates,Galina Yamshchikov,Jamie G. Saunders,LaSonji A. Holman,Mary E. Enama,Adam DeZure,Rebecca M. Lynch,Ingelise J. Gordon,Sarah A. Plummer,Cynthia S. Hendel,Amarendra Pegu,Michelle Conan-Cibotti,Sandra Sitar,Robert T. Bailer,Sandeep Narpala,Adrian B. McDermott,Mark K. Louder,Sijy O'Dell,Sankar Mohan,Janardan P. Pandey,Richard M. Schwartz,Zonghui Hu,Richard A. Koup,Edmund V. Capparelli,John R. Mascola,Barney S. Graham +26 more
TL;DR: The human monoclonal antibody VRC01 was well tolerated when delivered i.v. or s.c. and demonstrated expected half‐life and pharmacokinetics for a human immunoglobulin G.mAb, and dosing schedules for planning HIV‐1 prevention efficacy studies are informed.
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FTIR and Raman studies on benzimidazole
TL;DR: In this paper, the FTIR and laser Raman spectra of benzimidazole have been recorded and the observed frequencies were assigned to various modes of vibrations on the basis of normal coordinate calculations, assuming C s point group symmetry.