N
Nils Ole Schmidt
Researcher at University of Hamburg
Publications - 104
Citations - 4386
Nils Ole Schmidt is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Glioma. The author has an hindex of 24, co-authored 78 publications receiving 3770 citations. Previous affiliations of Nils Ole Schmidt include University Hospital Regensburg & Brigham and Women's Hospital.
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Journal ArticleDOI
A bioinformatic assay for pluripotency in human cells
Franz-Josef Müller,Bernhard M. Schuldt,Roy Williams,Dylan Mason,Gulsah Altun,Eirini P. Papapetrou,Sandra Danner,Johanna E. Goldmann,Johanna E. Goldmann,Arne Herbst,Nils Ole Schmidt,Josef B. Aldenhoff,Louise C. Laurent,Louise C. Laurent,Jeanne F. Loring +14 more
TL;DR: PluriTest is reported, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles that allows for indirect methods such as differentiation into teratomas in immunodeficient mice.
Journal ArticleDOI
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.
Albert Lai,Samir Kharbanda,Whitney B. Pope,Anh Tran,Orestes E. Solis,Franklin Peale,William F. Forrest,Kanan Pujara,Jose Carrillo,Ajay Pandita,Benjamin M. Ellingson,Chauncey W. Bowers,Robert Soriano,Nils Ole Schmidt,Sankar Mohan,William H. Yong,Somasekar Seshagiri,Zora Modrusan,Zhaoshi Jiang,Kenneth Aldape,Paul S. Mischel,Linda M. Liau,Cameron Escovedo,Weidong Chen,Phioanh L. Nghiemphu,C. David James,Michael D. Prados,Manfred Westphal,Katrin Lamszus,Timothy F. Cloughesy,Heidi S. Phillips,Heidi S. Phillips +31 more
TL;DR: Although histologically similar, GBMs arising with and without IDH1(R132MUT) appear to represent distinct disease entities that arise from separate cell types of origin as the result of largely nonoverlapping sets of molecular events.
Journal ArticleDOI
Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria
Hauke S. Günther,Nils Ole Schmidt,Heidi S. Phillips,Dirk Kemming,Samir Kharbanda,Robert Soriano,Zora Modrusan,Hildegard Meissner,Manfred Westphal,Katrin Lamszus +9 more
TL;DR: The generation of another distinct cluster of cell lines showing similarly homogeneous profiling but restricted stem cell properties suggests that different phenotypes exist, each of which may lead to the typical appearance of glioblastoma.
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Regulatory networks define phenotypic classes of human stem cell lines
Franz-Josef Müller,Franz-Josef Müller,Louise C. Laurent,Louise C. Laurent,Dennis Kostka,Igor Ulitsky,Roy Williams,Christina Lu,In-Hyun Park,Mahendra S. Rao,Mahendra S. Rao,Ron Shamir,Philip H. Schwartz,Philip H. Schwartz,Nils Ole Schmidt,Jeanne F. Loring,Jeanne F. Loring +16 more
TL;DR: A database of global gene expression profiles that enables the classification of cultured human stem cells in the context of a wide variety of pluripotent, multipotent and differentiated cell types is created and analysis of this database offers a new strategy for classifying stem cells.
Journal ArticleDOI
Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
Nils Ole Schmidt,Manfred Westphal,Christian Hagel,Süleyman Ergün,Dimitrios Stavrou,Eliot M. Rosen,Katrin Lamszus +6 more
TL;DR: Upon induction of angiogenesis in high‐grade tumors, bFGF may synergize with rising levels of not only VEGF but possibly also with HGF/SF, which appears here to be an independent angiogenic factor.