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Colin K. Watanabe
Researcher at Genentech
Publications - 161
Citations - 9697
Colin K. Watanabe is an academic researcher from Genentech. The author has contributed to research in topics: Nucleic acid & Nucleic acid methods. The author has an hindex of 28, co-authored 161 publications receiving 9031 citations.
Papers
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Journal ArticleDOI
GMAP: a genomic mapping and alignment program for mRNA and EST sequences
Thomas D. Wu,Colin K. Watanabe +1 more
TL;DR: GMAP, a standalone program for mapping and aligning cDNA sequences to a genome with minimal startup time and memory requirements, and provides fast batch processing of large sequence sets, demonstrates a several-fold increase in speed over existing programs.
Journal ArticleDOI
Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.
William J. Henzel,Todd M. Billeci,John T. Stults,Susan C. Wong,Christopher Grimley,Colin K. Watanabe +5 more
TL;DR: A rapid method for the identification of known proteins separated by two-dimensional gel electrophoresis is described in which molecular masses of peptide fragments are used to search a protein sequence database and each protein was uniquely identified from over 91,000 protein sequences.
Patent
Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same
Kevin P. Baker,Maureen Beresini,Laura DeForge,Luc Desnoyers,Ellen Filvaroff,Wei-Qiang Gao,Mary E. Gerritsen,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Steven Sherwood,Victoria Smith,Timothy A. Stewart,Daniel Tumas,Colin K. Watanabe,William I. Wood,Zemin Zhang +16 more
TL;DR: In this paper, the present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polyptides, and vectors and host cells comprising those nucleic amino acid sequences.
Journal ArticleDOI
WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors
Diane Pennica,Todd A. Swanson,James W. Welsh,Margaret Ann Roy,David A. Lawrence,James Lee,Jennifer Brush,Lisa A. Taneyhill,Bethanne Deuel,Michael Lew,Colin K. Watanabe,Robert L. Cohen,Mona F. Melhem,Gene Grant Finley,Phil Quirke,Audrey Goddard,Kenneth J. Hillan,Austin L. Gurney,David Botstein,David Botstein,Arnold J. Levine +20 more
TL;DR: The identification of two genes, WISP-1 and W ISP-2, that are up-regulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not by Wnnt-4 are reported, suggesting that the WISp genes may be downstream of WNT-1 signaling and that aberrant levels of WISPs expression in colon cancer may play a role in colon tumorigenesis.
Patent
Compositions and methods for the treatment of immune related diseases
Sherman Fong,Audrey Goddard,Paul J. Godowski,Christopher J. Grimaldi,Austin L. Gurney,Kenneth J. Hillan,Daniel Tumas,Colin K. Watanabe,William I. Wood,Zemin Zhang +9 more
TL;DR: In this article, a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases is presented, which relates to a composition consisting of novel proteins containing novel protein and methods.