S
Santosh J. Gharpure
Researcher at Indian Institute of Technology Bombay
Publications - 117
Citations - 1776
Santosh J. Gharpure is an academic researcher from Indian Institute of Technology Bombay. The author has contributed to research in topics: Intramolecular force & Total synthesis. The author has an hindex of 23, co-authored 109 publications receiving 1564 citations. Previous affiliations of Santosh J. Gharpure include Indian Institute of Science & Indiana University.
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Journal ArticleDOI
Enantioselective total synthesis of the potent antitumor agent (-)-mucocin using a temporary silicon-tethered ring-closing metathesis cross-coupling reaction.
TL;DR: This synthesis stimulated the development of a new approach for the construction of 3-hydroxy-2,6-disubstituted tetrahydropyrans, using the bismuth tribromide-mediated reductive etherification reaction, which represents a motif that is prevalent in a wide range of pharmacologically significant natural products.
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Stereoselective Construction of cis-2,6-Disubstituted Tetrahydropyrans via the Reductive Etherification of δ-Trialkylsilyloxy Substituted Ketones: Total Synthesis of (—)-Centrolobine
TL;DR: The stereoselective intramolecular reductive etherification of delta-trialkylsilyloxy substituted ketones with catalytic bismuth tribromide and triethylsilane provides a convenient method for the construction of cis-2,6-disubstituted tetrahydropyrans.
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A central strategy for converting natural products into fluorescent probes.
Matthew D Alexander,Michael D. Burkart,Michael S. Leonard,Padma Portonovo,Bo Liang,Xiaobin Ding,Madeleine M. Joullié,Brian M. Gulledge,James B. Aggen,A. Richard Chamberlin,Joel S. Sandler,William Fenical,Jian Cui,Santosh J. Gharpure,Alexei Polosukhin,Hai Ren Zhang,P. Andrew Evans,Adam D. Richardson,Mary Kay Harper,Chris M. Ireland,Binh G. Vong,Thomas P. Brady,Emmanuel A. Theodorakis,James J. La Clair +23 more
TL;DR: A Central Strategy for Converting Natural Products into Fluorescent Probes Matthew D. Alexander, Michael D. Burkart, Michael S. Leonard, and Padma Portonovo.
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Stereoselective construction of cyclic ethers using a tandem two-component etherification: elucidation of the role of bismuth tribromide.
TL;DR: The synthetic utility of this protocol is highlighted in the ability to construct adjacent tertiary ethers in a highly stereoselective manner and the development of a sequential two-component cross-coupling followed by reductive etherification process for the expeditious synthesis of nonadjacent tetrahydropyran rings.
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Stereoselective synthesis of donor-acceptor substituted cyclopropafuranones by intramolecular cyclopropanation of vinylogous carbonates: divergent synthesis of tetrahydrofuran-3-one, tetrahydropyran-3-one, and lactones.
TL;DR: A new, highly stereoselective intramolecular cyclopropanation of vinylogous carbonate with carbenes using copper catalyst is described, leading to a diverse array of frameworks such as tetrahydrofuran-3-one, tetrahYDropyran- 3- one, and lactones.