S
Santosh Kumar
Researcher at Johns Hopkins University
Publications - 12
Citations - 147
Santosh Kumar is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Disease & Pathogenesis. The author has an hindex of 5, co-authored 10 publications receiving 74 citations.
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Journal ArticleDOI
Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients
Ashutosh Kumar,Muneeb A. Faiq,Vikas Pareek,Khursheed Raza,Ravi K. Narayan,Pranav Prasoon,Pavan Kumar,Maheswari Kulandhasamy,Chiman Kumari,Kamla Kant,Himanshu Narayan Singh,Rizwana Qadri,Sada N. Pandey,Santosh Kumar +13 more
TL;DR: It is hypothesize that SARS-CoV-2 host cell entry receptor—ACE2 based mechanism in GI tissue may be involved in COVID-19 in the pathogenesis of digestive symptoms, in increased diabetic complications, and in disease recurrence.
Journal ArticleDOI
COVID-19 Mechanisms in the Human Body-What We Know So Far.
Ashutosh Kumar,Ravi K. Narayan,Pranav Prasoon,Chiman Kumari,Gurjot Kaur,Santosh Kumar,Maheswari Kulandhasamy,Kishore Sesham,Vikas Pareek,Muneeb A. Faiq,Sada N. Pandey,Himanshu Narayan Singh,Kamla Kant,Prakash Singh Shekhawat,Khursheed Raza,Sujeet Kumar +15 more
TL;DR: A review of the progress made since the commencement of the COVID-19 pandemic can be found in this article, where the authors narrate the progress in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors.
Journal ArticleDOI
Broad-spectrum non-nucleoside inhibitors of human herpesviruses
Lora McClain,Yun Zhi,Hoyee Cheng,Ayantika Ghosh,Paolo Piazza,Michael B. Yee,Santosh Kumar,Jadranka Milosevic,David C. Bloom,Ravit Arav-Boger,Paul R. Kinchington,Robert H. Yolken,Vishwajit L. Nimgaonkar,Leonardo D'Aiuto +13 more
TL;DR: Five compounds with predicted lysosomotropic activity showed antiviral activity comparable to ACV during lytic herpes simplex virus type 1 (HSV-1) infections, reduced viral DNA copy number, and reduced selected HSV- 1 protein levels; these compounds also inhibited the reactivation of 'quiescent' HSv-1 infection established in iPSC-neurons, but did not inhibit viral entry into host cells.
Posted ContentDOI
Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients
Ashutosh Kumar,Muneeb A. Faiq,Vikas Pareek,Khursheed Raza,Ravi K. Narayan,Pranav Prasoon,Pavan Kumar,Maheswari Kulandhasamy,Chiman Kumari,Kamla Kant,Himanshu Narayan Singh,Rizwana Qadri,Sada N. Pandey,Santosh Kumar +13 more
TL;DR: It is proposed that a SARS-CoV-2 binding with ACE2 mediates dysregulation of the sodium dependent nutrient transporters and hence may be a plausible basis for the digestive symptoms in COVID-19 patients.
Student's Corner Byssinosis: As seen in cotton spinning mill workers of Karachi
Mohammed Irfan Farooque,Bushra Khan,Erum Aziz,Mehreen Moosa,Mohammed Raheel,Santosh Kumar,Farah Asad Mansuri +6 more
TL;DR: In this paper, a study was conducted in a cotton spinning mill of Karachi in June 2006 to identify byssinosis in cotton mill workers, probable associations of disease with factors such as different work areas, safety gadget usage and overtime and to ascertain proportions of byssinsosis to accidental injuries.