Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients
Ashutosh Kumar,Muneeb A. Faiq,Vikas Pareek,Khursheed Raza,Ravi K. Narayan,Pranav Prasoon,Pavan Kumar,Maheswari Kulandhasamy,Chiman Kumari,Kamla Kant,Himanshu Narayan Singh,Rizwana Qadri,Sada N. Pandey,Santosh Kumar +13 more
TLDR
It is hypothesize that SARS-CoV-2 host cell entry receptor—ACE2 based mechanism in GI tissue may be involved in COVID-19 in the pathogenesis of digestive symptoms, in increased diabetic complications, and in disease recurrence.Citations
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COVID-19 and metabolic disease: mechanisms and clinical management.
Charlotte Steenblock,Peter Schwarz,Barbara Ludwig,Andreas Linkermann,Paul Zimmet,Konstantin Y. Kulebyakin,Vsevolod A. Tkachuk,Alexander G. Markov,Hendrik Lehnert,Martin Hrabě de Angelis,Hannes Rietzsch,Roman N. Rodionov,Kamlesh Khunti,David Hopkins,Andreas L. Birkenfeld,Bernhard O. Boehm,Richard I. G. Holt,Jay S. Skyler,J. Hans DeVries,Eric Renard,Robert H. Eckel,K. George M.M. Alberti,Bruno Geloneze,Juliana C.N. Chan,Jean Claude Mbanya,Henry Chijioke Onyegbutulem,Ambady Ramachandran,Abdul Basit,Mohamed Hassanein,Gavin A. Bewick,Giatgen A. Spinas,Felix Beuschlein,Rüdiger Landgraf,Francesco Rubino,Geltrude Mingrone,Stefan R. Bornstein +35 more
TL;DR: In this paper, the authors provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19 and post-pandemic.
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COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus
Hayder M Al-Kuraishy,Ali I Al-Gareeb,M. Alblihed,Susana G. Guerreiro,Susana G. Guerreiro,Natália Cruz-Martins,Gaber El-Saber Batiha +6 more
TL;DR: Wang et al. as discussed by the authors provided an overview of the potential link between COVID-19 and hyperglycemia as a risk factor for DM development in relation to DM pharmacotherapy.
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COVID-19 and the digestive system: A comprehensive review
Ming-Ke Wang,Hai-Yan Yue,Jin Cai,Yu-Jia Zhai,Jian-Hui Peng,Ju-Fen Hui,Deng-Yong Hou,Wei-Peng Li,Jishun Yang +8 more
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COVID-19 Mechanisms in the Human Body-What We Know So Far.
Ashutosh Kumar,Ravi K. Narayan,Pranav Prasoon,Chiman Kumari,Gurjot Kaur,Santosh Kumar,Maheswari Kulandhasamy,Kishore Sesham,Vikas Pareek,Muneeb A. Faiq,Sada N. Pandey,Himanshu Narayan Singh,Kamla Kant,Prakash Singh Shekhawat,Khursheed Raza,Sujeet Kumar +15 more
TL;DR: A review of the progress made since the commencement of the COVID-19 pandemic can be found in this article, where the authors narrate the progress in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors.
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Neurological Symptoms of COVID-19: The Zonulin Hypothesis.
TL;DR: In this paper, the authors proposed an alternative pathway from the infection of the gut, involving Toll-like receptor 4 (TLR4), zonulin, protease-activated receptor 2 (PAR2), and Zonulin brain receptor.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
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