S
Sanyukta Rana
Researcher at Heidelberg University
Publications - 12
Citations - 2679
Sanyukta Rana is an academic researcher from Heidelberg University. The author has contributed to research in topics: Exosome & Microvesicles. The author has an hindex of 11, co-authored 12 publications receiving 2250 citations. Previous affiliations of Sanyukta Rana include University of Bremen.
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Journal ArticleDOI
Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Irina Nazarenko,Sanyukta Rana,Alexandra Baumann,Jessica McAlear,Andrea Hellwig,Michael Trendelenburg,Günter Lochnit,Klaus T. Preissner,Margot Zöller +8 more
TL;DR: EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors, which could provide new options for therapeutic interference with tumor-induced angiogenesis.
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Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection
TL;DR: This is the first report on the exosomal tetraspanin web contributing to target cell selection such that predictions can be made on potential targets, which will facilitate tailoring exosomes for drug delivery.
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Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity.
Bindhu Madhavan,Shijing Yue,Uwe Galli,Sanyukta Rana,Wolfgang Gross,Miryam Müller,Nathalia A. Giese,Holger Kalthoff,Thomas Becker,Markus W. Büchler,Margot Zöller +10 more
TL;DR: The concomitant evaluation of PaCIC and PaCa‐related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally‐invasive PaCa diagnostics.
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Exosomal tumor microRNA modulates premetastatic organ cells.
TL;DR: Fitting the demands of metastasizing tumor cells, transferred exosomal miRNA mostly affected proteases, adhesion molecules, chemokine ligands, cell cycle- and angiogenesis-promoting genes, and genes engaged in oxidative stress response.
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Host matrix modulation by tumor exosomes promotes motility and invasiveness.
TL;DR: The host tissue ECM modulation by TEX is an important factor in the cross talk between a tumor and the host including premetastatic niche preparation and the recruitment of hematopoietic cells.