Exosomal tumor microRNA modulates premetastatic organ cells.
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TLDR
Fitting the demands of metastasizing tumor cells, transferred exosomal miRNA mostly affected proteases, adhesion molecules, chemokine ligands, cell cycle- and angiogenesis-promoting genes, and genes engaged in oxidative stress response.About:
This article is published in Neoplasia.The article was published on 2013-03-01 and is currently open access. It has received 304 citations till now. The article focuses on the topics: Exosome & Microvesicles.read more
Citations
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Exosome and exosomal microRNA: trafficking, sorting, and function.
TL;DR: The origin and the trafficking of exosomes between cells are introduced, current research on the sorting mechanism ofExosomal miRNAs is displayed, and how exosome and their miRNA-containing vesicles function in recipient cells are described.
Journal ArticleDOI
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Annette Becker,Basant Kumar Thakur,Joshua Mitchell Weiss,Han Sang Kim,Han Sang Kim,Héctor Peinado,David Lyden +6 more
TL;DR: Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
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Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review
TL;DR: It is proposed that the successful combination of cancer treatments to tackle exosome-mediated drug resistance requires an interdisciplinary understanding of these cellular exclusion mechanisms, and how secreted biomolecules are involved in cellular cross-talk within the tumor microenvironment.
Journal ArticleDOI
Extracellular vesicles in cancer - implications for future improvements in cancer care.
TL;DR: A review of the biophysical properties and physiological functions of extracellular vesicles, particularly their pro-metastatic effects, and highlight the utility of EVs for the development of cancer diagnostics and therapeutics can be found in this paper.
Journal ArticleDOI
Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
TL;DR: The origin and structure of exosomes as well as their biological functions are outlined and specific applications of exOSomes as drug delivery systems in pharmaceutical drug development are focused on.
References
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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
Journal ArticleDOI
Exosomes: extracellular organelles important in intercellular communication.
TL;DR: This review focuses on various strategies for purifying exosomes and discusses their biophysical and biochemical properties, and an update on proteomic analysis of exosome from various cell types and body fluids is provided and host-cell specific proteomic signatures are discussed.
Journal ArticleDOI
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Nobuyoshi Kosaka,Haruhisa Iguchi,Yusuke Yoshioka,Fumitaka Takeshita,Yasushi Matsuki,Takahiro Ochiya +5 more
TL;DR: It is shown that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAAs are transferable and functional in the recipient cells and that a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipients cells, thereby leading to cell growth inhibition.
Journal ArticleDOI
A new variant of glycoprotein cd44 confers metastatic potential to rat carcinoma cells
U. Günthert,Martin Hofmann,Wolfgang Rudy,S. Reber,Margot Zöller,Irmgard U. Haussmann,S. Matzku,A. Wenzel,Helmut Ponta,Peter Herrlich +9 more
TL;DR: Using a monoclonal antibody raised against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, cDNA clones have been isolated that encode glycoproteins with partial homology to CD44, a presumed adhesion molecule.
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