M
Miryam Müller
Researcher at University of Kiel
Publications - 18
Citations - 923
Miryam Müller is an academic researcher from University of Kiel. The author has contributed to research in topics: Glycoprotein 130 & Progenitor cell. The author has an hindex of 8, co-authored 16 publications receiving 648 citations. Previous affiliations of Miryam Müller include Heidelberg University.
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Journal ArticleDOI
Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity.
Bindhu Madhavan,Shijing Yue,Uwe Galli,Sanyukta Rana,Wolfgang Gross,Miryam Müller,Nathalia A. Giese,Holger Kalthoff,Thomas Becker,Markus W. Büchler,Margot Zöller +10 more
TL;DR: The concomitant evaluation of PaCIC and PaCa‐related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally‐invasive PaCa diagnostics.
Journal ArticleDOI
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
Tobias Schwerd,Twigg Srf.,Dominik Aschenbrenner,S Manrique,Kerry A. Miller,Indira B. Taylor,Melania Capitani,Simon J. McGowan,E Sweeney,Astrid Weber,L Chen,Paul Bowness,A Riordan,Andrew J. Cant,Alexandra F. Freeman,Joshua D. Milner,Steve M. Holland,N Frede,Miryam Müller,Dirk Schmidt-Arras,Bodo Grimbacher,Bodo Grimbacher,Steven A. Wall,E Y Jones,Wilkie Aom.,Holm H. Uhlig +25 more
TL;DR: A patient with a homozygous mutation of IL6ST (encoding GP130 p.N404Y) who presented with recurrent infections, eczema, bronchiectasis, high IgE, eosinophilia, defective B cell memory, and an impaired acute-phase response is identified with a novel immunodeficiency with phenotypic similarities to STAT3 hyper-IgE syndrome caused by loss of function of GP130.
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IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice
Juri Bergmann,Miryam Müller,Niklas Baumann,Manuel Reichert,Carola Heneweer,Julia Bolik,Karsten Lücke,Sabine Gruber,Antonella Carambia,Susanne Boretius,Ivo Leuschner,Thomas Becker,Björn Rabe,Johannes Herkel,F. Thomas Wunderlich,Hans-Willi Mittrücker,Stefan Rose-John,Dirk Schmidt-Arras +17 more
TL;DR: It is shown that specific inhibition of IL‐6 trans‐signaling is sufficient to blunt tumor initiation and impair tumor progression without compromising IL‐ 6 classic signaling‐driven protective immune responses.
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The landscape of gene mutations in cirrhosis and hepatocellular carcinoma.
TL;DR: The landscape of gene mutations in cirrhosis is reviewed, especially those paving the path toward HCC development characterised by recent studies capitalising on technological advances in genomic sequencing.
Journal ArticleDOI
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Jeanette Schwarz,Claudia Broder,Ansgard Helmstetter,Stefanie Schmidt,Isabell Yan,Miryam Müller,Dirk Schmidt-Arras,Christoph Becker-Pauly,Friedrich Koch-Nolte,Hans-Willi Mittrücker,Björn Rabe,Stefan Rose-John,Athena Chalaris +12 more
TL;DR: It is concluded that pro-TNFα cleavage by its major sheddase ADAM17 does not depend on cytosolic phosphorylation and/or interaction and these results have general implications on understanding the activation mechanism controlling the activity of ADAM 17.