S
Sapana Shah
Researcher at University of Pittsburgh
Publications - 7
Citations - 384
Sapana Shah is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Ulcerative colitis & Medicine. The author has an hindex of 3, co-authored 4 publications receiving 237 citations.
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Journal ArticleDOI
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Yael Haberman,Yael Haberman,Rebekah Karns,Phillip J. Dexheimer,Melanie Schirmer,Judith Somekh,Judith Somekh,Ingrid Jurickova,Tzipi Braun,Elizabeth Novak,Laura Bauman,Laura Bauman,Margaret H. Collins,Angela Mo,Michael J. Rosen,Erin Bonkowski,Nathan Gotman,Alison Marquis,Mason Nistel,Paul A. Rufo,Susan S. Baker,Cary G. Sauer,James Markowitz,Marian D. Pfefferkorn,Joel R. Rosh,Brendan M. Boyle,David R. Mack,Robert N. Baldassano,Sapana Shah,Neal S. Leleiko,Melvin B. Heyman,Anne M. Grifiths,Ashish S. Patel,Joshua D. Noe,Bruce J. Aronow,Subra Kugathasan,Thomas D. Walters,Greg Gibson,Sonia Davis Thomas,Sonia Davis Thomas,Kevin P. Mollen,Shai S. Shen-Orr,Curtis Huttenhower,Ramnik J. Xavier,Jeffrey S. Hyams,Lee A. Denson +45 more
TL;DR: In this article, the authors used RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric ulcerative colitis patients receiving standardised therapy.
Journal ArticleDOI
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium
Misty Good,Richard Siggers,Chhinder P. Sodhi,Amin Afrazi,Feras Alkhudari,Charlotte E. Egan,Matthew D. Neal,Ibrahim Yazji,Hongpeng Jia,Joyce Lin,Maria F. Branca,Congrong Ma,Thomas Prindle,Zachary Grant,Sapana Shah,Dennis Slagle,Jose Paredes,John A. Ozolek,George K. Gittes,David J. Hackam +19 more
TL;DR: It is shown that microinjection of amniotic fluid into the fetal gastrointestinal tract reduced LPS-mediated signaling within the fetal intestinal mucosa, which may explain the unique susceptibility of premature infants to the development of NEC and offer therapeutic approaches to this devastating disease.
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Yael Haberman,Yael Haberman,Rebekah Karns,Phillip J. Dexheimer,Melanie Schirmer,Judith Somekh,Judith Somekh,Ingrid Jurickova,Tzipi Braun,Elizabeth Novak,Laura Bauman,Laura Bauman,Margaret H. Collins,Angela Mo,Michael J. Rosen,Erin Bonkowski,Nathan Gotman,Alison Marquis,Mason Nistel,Paul A. Rufo,Susan S. Baker,Cary G. Sauer,James Markowitz,Marian D. Pfefferkorn,Joel R. Rosh,Brendan M. Boyle,David R. Mack,Robert N. Baldassano,Sapana Shah,Neal S. Leleiko,Melvin B. Heyman,Anne M. Grifiths,Ashish S. Patel,Joshua D. Noe,Bruce J. Aronow,Subra Kugathasan,Thomas D. Walters,Greg Gibson,Sonia Davis Thomas,Sonia Davis Thomas,Kevin P. Mollen,Shai S. Shen-Orr,Curtis Huttenhower,Ramnik J. Xavier,Jeffrey S. Hyams,Lee A. Denson +45 more
TL;DR: Examination of rectal gene expression signatures and faecal microbiomes of children and adults with ulcerative colitis provides insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
Journal ArticleDOI
Optic pathway glioma as part of a constitutional mismatch-repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1.
Jacky T. Yeung,Ian F. Pollack,Sapana Shah,Ronald Jaffe,Marina N. Nikiforova,Regina I. Jakacki +5 more
TL;DR: The case of a 3‐year‐old male with an extensive OPG who met the diagnostic criteria for NF‐1 was reported, and he was subsequently found to have multiple colonic polyps and bi‐allelic loss of PMS2.