Melvin B. Heyman

TL;DR: These CD-specific host and microbe profiles identify the ileum as the primary inductive site for all forms of CD and may direct prognostic and therapeutic approaches.

TL;DR: In this article, the authors used RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric ulcerative colitis patients receiving standardised therapy.

TL;DR: The role of the gut microbiome in disease course for 405 pediatric, new-onset, treatment-naive ulcerative colitis patients was evaluated in PROTECT as mentioned in this paper, where patients were monitored for 1 year upon treatment initiation, and microbial taxonomic composition was analyzed from fecal samples and rectal biopsies.

TL;DR: It is shown that TRSs based on genes regulated by variants linked to inflammatory bowel disease not only outperform genetic risk scores (GRSs) in distinguishing Crohn's disease from healthy samples, but also serve to identify patients who in time will progress to complicated disease.

TL;DR: Examination of rectal gene expression signatures and faecal microbiomes of children and adults with ulcerative colitis provides insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.