S
Sarah Kim
Researcher at University of Bonn
Publications - 11
Citations - 3256
Sarah Kim is an academic researcher from University of Bonn. The author has contributed to research in topics: RNA & Pattern recognition receptor. The author has an hindex of 10, co-authored 11 publications receiving 3002 citations. Previous affiliations of Sarah Kim include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
5'-Triphosphate RNA Is the Ligand for RIG-I
Veit Hornung,Jana M. Ellegast,Sarah Kim,Krzysztof Brzózka,Andreas Jung,Hiroki Kato,Hendrik Poeck,Shizuo Akira,Karl-Klaus Conzelmann,Martin Schlee,Stefan Endres,Gunther Hartmann +11 more
TL;DR: It is demonstrated that the 5′-triphosphate end of RNA generated by viral polymerases is responsible for retinoic acid–inducible protein I (RIG-I)–mediated detection of RNA molecules in viruses known to be detected by MDA-5 such as the picornaviruses.
Journal ArticleDOI
Inflammasomes: current understanding and open questions
Franz Bauernfeind,Andrea Ablasser,Eva Bartok,Sarah Kim,Jonathan L. Schmid-Burgk,Taner Cavlar,Veit Hornung +6 more
TL;DR: Current knowledge of mechanisms leading to the activation of inflammasomes is reviewed and the controversial molecular mechanisms that regulate NLRP3 signaling are focused on and recent advancements in DNA sensing by the inflammaome receptor AIM2 are highlighted.
Journal ArticleDOI
Listeria monocytogenes is sensed by the NLRP3 and AIM2 Inflammasome
Sarah Kim,Franz Bauernfeind,Andrea Ablasser,Gunther Hartmann,Katherine A. Fitzgerald,Eicke Latz,Eicke Latz,Veit Hornung +7 more
TL;DR: A role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria is established in the recognition and containment of various microbial pathogens.
Journal ArticleDOI
Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.
Andrea Ablasser,Hendrik Poeck,David Anz,Michael Berger,Martin Schlee,Sarah Kim,Carole Bourquin,Nadege Goutagny,Zhaozhao Jiang,Katherine A. Fitzgerald,Simon Rothenfusser,Stefan Endres,Gunther Hartmann,Veit Hornung +13 more
TL;DR: The results uncover the potential of monocytes to function as major producers of IL-12p70, a key Th1 cytokine classically ascribed to myeloid dendritic cells that cannot be induced by CpG oligonucleotides in the human system.
Journal ArticleDOI
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Sarah Kim,Jessica Becker,Matthias Bechheim,Vera Kaiser,Mahdad Noursadeghi,Nadine Fricker,Esther Beier,Sven Klaschik,Peter Boor,Timo Hess,Andrea Hofmann,Stefan Holdenrieder,Jens R. Wendland,Holger Fröhlich,Gunther Hartmann,Markus M. Nöthen,Bertram Müller-Myhsok,Benno Pütz,Veit Hornung,Johannes Schumacher +19 more
TL;DR: Novel insights are presented into the genetic basis of the innate immune response and the value of eQTL studies in the context of exogenous cell stimulation is exemplified.