Jana M. Ellegast

TL;DR: It is demonstrated that the 5′-triphosphate end of RNA generated by viral polymerases is responsible for retinoic acid–inducible protein I (RIG-I)–mediated detection of RNA molecules in viruses known to be detected by MDA-5 such as the picornaviruses.

TL;DR: In this paper, the authors transplanted mobilized peripheral blood (PB) CD34+ cells in sublethally irradiated newborn and adult recipients and found that the transplanted PB cells showed higher engraftment levels in bone marrow, spleen, and PB in newborn transplanted MSTRG/MISTRG as compared with nonobese diabetic/severe combined immunodeficient Il2rg-/- or human SIRPα-transgenic Rag2-/-Il2rg+/- recipients.

TL;DR: HSP90 inhibition depletes STK33 in KRAS mutant tumors in KRas mutant tumors and results in down-regulation of HSP90 activity in these patients with KRAS mutated tumors.

TL;DR: The results indicate that RET-mTORC1 signaling promotes AML through autophagy suppression, suggesting that targeting RET or, more broadly, depletion of leukemogenic drivers via Autophagy induction provides a therapeutic opportunity in a relevant subset of AML patients.

TL;DR: This work employs high-throughput screening to discover a lead chemical scaffold, the benzothiazolopyrimidones, that allosterically inhibits this oncogenic phosphatase by simultaneously engaging the C-SH2 and PTP domains.