Sarah Pambianco

TL;DR: This paper showed that autophagy is severely impaired in muscles from patients affected by Duchenne muscular dystrophy and mdx mice, a model of the disease, with accumulation of damaged organelles.

TL;DR: It is shown that mitochondrial elongation is required for myogenesis to occur and that this event depends on the cellular generation of nitric oxide (NO), and that these effects of NO inhibition were not observed in myogenic precursor cells containing a dominant-negative form of Drp1.

TL;DR: The results indicate that nNOSμ/NO is required to regulate key homeostatic mechanisms in skeletal muscle, namely mitochondrial bioenergetics and network remodelling, UPRmt and autophagy.

TL;DR: The fact that A-SMase in melanomas affects mTOR-regulated autophagy and plays a central role in cisplatin efficacy encourages pre-clinical testing on the modulation of A- SMase levels/activity as possible novel anti-neoplastic strategy.

TL;DR: The data provide a pre‐clinical proof‐of‐concept that targeting Numb/p53 results in a specific anti‐CSC therapy in human BCs and corrected the defective self‐renewal properties of Numb‐deficient CSCs and inhibited CSC expansion, with a marked effect on tumorigenicity and metastasis.